Autoantibodies against aquaporin-4 in patients with neuropsychiatric systemic lupus erythematosus and primary Sjogren's syndrome.

摘要

Neurologic manifestations occur in up to 70% of patients with systemic lupus erythematosus (SLE) and in approx20% of patients with Sjogren's syndrome (SS) and are associated with significant morbidity. There is as yet no biologic marker that specifically indicates neurologic involvement in rheumatic diseases. In the literature to date, the association between nervous system manifestations of SLE and autoantibodies against ribosomal P proteins and N-methyl-D-aspartate receptor has been inconsistently demonstrated (1).