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首页> 外文期刊>Archivum immunologiae et therapiae experimentalis >Exocrine Gland Morphogenesis: Insights into the Role of Amphiregulin from Development to Disease
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Exocrine Gland Morphogenesis: Insights into the Role of Amphiregulin from Development to Disease

机译:外分泌腺形态发生:洞察Amphiregulin从发育到疾病的角色

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摘要

Abstract Amphiregulin (AREG) is a well-characterized member of the epidermal growth factor (EGF) family and is one of the ligands of the EGF receptor (EGFR). AREG plays a key role in mammalian development and in the control of branching morphogenesis in various organs. Furthermore, AREG participates in a wide range of physiological and pathological processes activating the major intracellular signalling cascades governing cell survival, proliferation and motility. In this article, we review current advances in exocrine glands morphogenesis, focusing on the salivary gland, and discuss the essential aspects of AREG structure, function and regulation, and its differential role within the EGFR family of ligands. Finally, we identify emerging aspects in AREG research applied to mammary gland development and the salivary gland autoimmune disease, Sj?gren’s syndrome.
机译:摘要Ampheregulin(ISG)是表皮生长因子(EGF)家族的良好表征成员,是EGF受体(EGFR)的配体之一。 ISG在哺乳动物的发展中起着关键作用,并在各种器官中控制分枝形态发生。 此外,ISG参与各种生理和病理方法,激活治疗细胞存活,增殖和运动的主要细胞内信号传导级联。 在本文中,我们审查了进口腺体形态发生的目前进展,重点涉及唾液腺,并讨论了均值结构,功能和调节的基本方面,以及其在联合品的EGFR系列内的差异作用。 最后,我们确定患有乳腺发育和唾液腺自身免疫疾病的新兴的方面,SJ?Gren的综合征。

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