Internal exposure to carcinogenic polycyclic aromatic hydrocarbons and DNA damage.

摘要

In the August issue of the Archives, Kafferlein et al. report no association between occupational exposures to polycy-clic aromatic hydrocarbons (PAHs) and deoxyribo nucleic acid (DNA) damage on the individual level (Kafferlein et al. 2012). Internal PAH exposure, assessed in a variety of occupations by means of urinary 3-hydroxy benzo[a]pyr-ene (3-OH-B[a]P) and 1- and 2-naphtol (OHNaph), was unrelated with DNA strand break frequencies and the levels of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dGuo), perhaps with the exception of a small group of converter workers where an uncertain correlation between ]TOHNaph and 8-oxo-dGuo was observed. Authors discuss reasons for this lack of association suggesting to focus on the individual exposure circumstances. These include possible different routes of exposure and co-exposures and a better understanding and assessment of the kinetics and dynamics of the endpoints.