Immunological Indicators in Dogs Affected by Deep Pyoderma

摘要

We examined the immune state of dogs with deep pyoderma to elucidate the relationshipbetween clinical symptoms and immunological processes. We measured selected immunologicalparameters in control dogs (n = 10) and dogs of various breeds (German Shepherds were notincluded) affected by deep pyoderma (n = 25). We found that the affected dogs had increasedrelative counts of neutrophils, decreased relative and absolute counts of lymphocytes, higherrelative counts of CD3+ lymphocytes and CD8+ lymphocytes but lower relative counts of CD21 +lymphocytes and CD4+ lymphocytes. The affected dogs exhibited a reduced activity of non-stimulated as well as mitogen-stimulated lymphocytes. Lower values of circulating immunecomplexes (CIC) in affected dogs were conditioned by the young age of animals. Nevertheless, thechanges found in our study were not expressed in all animals.