Operculina turpethum extract inhibits growth and proliferation by inhibiting NF-kappa B, COX-2 and cyclin D1 and induces apoptosis by up regulating P53 in oral cancer cells

摘要

Objectives: Herbal drugs are popularly emerging as complementary and alternative medicines in cancer patients because of their cost effectiveness and minimal side-effects. The extract of Operculina turpethum (OT) is known to have antipyretic, anti-inflammatory and purgative properties. Since it is popularly known have antiinflammatory activity, we investigated its anti-tumor activity on four oral squamous cell carcinoma cell lines (OSCC) namely, (SCC-4, KB, SCC-9 and SCC-25).