iNOS-Derived Nitric Oxide Induces Integrin-Linked Kinase Endocytic Lysosome-Mediated Degradation in the Vascular Endothelium

Reventun Paula; Alique Matilde; Cuadrado Irene; Marquez Susana; Toro Rocio; Zaragoza Carlos; Saura Marta

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iNOS-Derived Nitric Oxide Induces Integrin-Linked Kinase Endocytic Lysosome-Mediated Degradation in the Vascular Endothelium

机译：Inos衍生的一氧化氮诱导整联蛋白连接的激酶内胶质溶酶体介导的血管内皮中的降解

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Objective-ILK (integrin-linked kinase) plays a key role in controlling vasomotor tone and is decreased in atherosclerosis. The objective of this study is to test whether nitric oxide (NO) regulates ILK in vascular remodeling.

机译：Objective-Ilk（Integin-Linked激酶）在控制血管血管色调中起着关键作用，在动脉粥样硬化中减少。本研究的目的是测试一氧化氮（NO）是否调节血管重塑中的ILK。

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来源
《Arteriosclerosis, thrombosis, and vascular biology》 |2017年第7期|共10页
作者
Reventun Paula; Alique Matilde; Cuadrado Irene; Marquez Susana; Toro Rocio; Zaragoza Carlos; Saura Marta;
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作者单位

Univ Alcala IRYCIS Sch Med &

Hlth Sci Dept Syst Biol Physiol Madrid Spain;

Univ Alcala IRYCIS Sch Med &

Hlth Sci Dept Syst Biol Physiol Madrid Spain;

Univ Alcala IRYCIS Sch Med &

Hlth Sci Dept Syst Biol Physiol Madrid Spain;

Cadiz Univ Sch Med Dept Cardiol Cadiz Spain;

Univ Francisco de Vitoria Hosp Ramon y Cajal Res Unit IRYCIS Dept Cardiol Madrid Spain;

Univ Alcala IRYCIS Sch Med &

Hlth Sci Dept Syst Biol Physiol Madrid Spain;

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原文格式 PDF
正文语种 eng
中图分类心脏、血管（循环系）疾病;
关键词
endocytosis; inflammation; mice; nitric oxide; nitric oxide synthase; vascular remodeling;

机译：内吞作用;炎症;小鼠;一氧化氮;一氧化氮合酶;血管重塑;

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专利

1. iNOS-Derived Nitric Oxide Induces Integrin-Linked Kinase Endocytic Lysosome-Mediated Degradation in the Vascular Endothelium [J] . Reventun Paula, Alique Matilde, Cuadrado Irene, Arteriosclerosis, thrombosis, and vascular biology . 2017,第7期

机译：Inos衍生的一氧化氮诱导整联蛋白连接的激酶内胶质溶酶体介导的血管内皮中的降解
2. Rho kinase contributes to basal vascular tone in humans: role of endothelium-derived nitric oxide. [J] . Bussemaker E, Pistrosch F, Forster S, American Journal of Physiology . 2007,第1期

机译：Rho激酶有助于人类的基础血管紧张：内皮源性一氧化氮的作用。
3. Polycaprolactone/gelatin degradable vascular grafts simulating endothelium functions modified by nitric oxide generation [J] . Regenerative medicine . 2019,第12期

机译：聚己内酯/明胶可降解血管移植物模拟通过一氧化氮产生改性的内皮型函数
4. Nitric oxide producing coating mimcking endothelium function for multifunctional vascular stens [C] . Zhilu Yang, Jin Wang, Nan Huang World biomaterials congress . 2016

机译：一氧化氮产生涂层，具有内皮功能，可用于多功能血管
5. Role of NAD(P)H oxidase-derived hydrogen peroxide in regulating inducible nitric oxide synthase expression in interleukin-1beta-stimulated vascular smooth muscle. [D] . Guikema, Benjamin J. 2006

机译：NAD（P）H氧化酶衍生的过氧化氢在白介素1β刺激的血管平滑肌中调节诱导型一氧化氮合酶表达的作用。
6. Long Non-coding RNA H19 Suppression Protects the Endothelium Against Hyperglycemic-Induced Inflammation via Inhibiting Expression of miR-29b Target Gene Vascular Endothelial Growth Factor a Through Activation of the Protein Kinase B/Endothelial Nitric Oxide Synthase Pathway [O] . Xiao-wen Cheng, Zhen-fei Chen, Yu-feng Wan, 2019

机译：长非编码RNA H19抑制通过抑制miR-29b靶基因血管内皮生长因子a的表达通过激活蛋白激酶B /内皮一氧化氮合酶途径保护内皮免受高血糖诱导的炎症
7. iNOS-Derived Nitric Oxide Induces Integrin-Linked Kinase Endocytic Lysosome-Mediated Degradation in the Vascular Endothelium [O] . Paula Reventun, Matilde Alique, Irene Cuadrado, 2017

机译：Inos衍生的一氧化氮在血管内皮中诱导整联蛋白连接的激酶内胶质溶酶体介导的降解

iNOS-Derived Nitric Oxide Induces Integrin-Linked Kinase Endocytic Lysosome-Mediated Degradation in the Vascular Endothelium

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