PI3K (Phosphoinositide 3-Kinase ) Regulates Vascular Smooth Muscle Cell Phenotypic Modulation and Neointimal Formation Through CREB (Cyclic AMP-Response Element Binding Protein)/YAP (Yes-Associated Protein) Signaling

摘要

Objective Vascular smooth muscle cells (VSMCs) phenotype modulation is critical for the resolution of vascular injury. Genetic and pharmacological inhibition of PI3K (phosphoinositide 3-kinase ) exerts anti-inflammatory and protective effects in multiple cardiovascular diseases. This study investigated the role of PI3K and its downstream effector molecules in the regulation of VSMC phenotypic modulation and neointimal formation in response to vascular injury.