Global skin gene expression analysis of early diffuse cutaneous systemic sclerosis shows a prominent innate and adaptive inflammatory profile

Skaug Brian; Khanna Dinesh; Swindell William R.; Hinchcliff Monique E.; Frech Tracy M.; Steen Virginia D.; Hant Faye N.; Gordon Jessica K.; Shah Ami A.; Zhu Lisha; Zheng W. Jim; Browning Jeffrey L.; Barron Alexander M. S.; Wu Minghua; Visvanathan Sudha; Baum Patrick; Franks Jennifer M.; Whitfield Michael L.; Shanmugam Victoria K.; Domsic Robyn T.; Castelino Flavia V.; Bernstein Elana J.; Wareing Nancy; Lyons Marka A.; Ying Jun; Charles Julio; Mayes Maureen D.; Assassi Shervin

首页> 外文期刊>Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research >Global skin gene expression analysis of early diffuse cutaneous systemic sclerosis shows a prominent innate and adaptive inflammatory profile

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Global skin gene expression analysis of early diffuse cutaneous systemic sclerosis shows a prominent innate and adaptive inflammatory profile

机译：早期弥漫性皮肤系统硬化症的全局皮肤基因表达分析显示出突出的天生和适应性炎症性

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Objectives Determine global skin transcriptome patterns of early diffuse systemic sclerosis (SSc) and how they differ from later disease.

机译：目标确定早期弥漫性系统硬化症（SSC）的全球皮肤转录组模式以及它们与后期疾病的不同。

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《Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research》 |2020年第3期|共8页
作者
Skaug Brian; Khanna Dinesh; Swindell William R.; Hinchcliff Monique E.; Frech Tracy M.; Steen Virginia D.; Hant Faye N.; Gordon Jessica K.; Shah Ami A.; Zhu Lisha; Zheng W. Jim; Browning Jeffrey L.; Barron Alexander M. S.; Wu Minghua; Visvanathan Sudha; Baum Patrick; Franks Jennifer M.; Whitfield Michael L.; Shanmugam Victoria K.; Domsic Robyn T.; Castelino Flavia V.; Bernstein Elana J.; Wareing Nancy; Lyons Marka A.; Ying Jun; Charles Julio; Mayes Maureen D.; Assassi Shervin;
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作者单位

Univ Texas Hlth Sci Ctr Houston Div Rheumatol &

Clin Immunogenet Houston TX 77030 USA;

Univ Michigan Dept Internal Med Div Rheumatol Scleroderma Program Ann Arbor MI 48109 USA;

Ohio Univ Heritage Coll Osteopath Med Athens OH 45701 USA;

Yale Univ Dept Med Sect Allergy Rheumatol &

Immunol New Haven CT 06520 USA;

Univ Utah Dept Internal Med Div Rheumatol Salt Lake City UT 84112 USA;

MedStar Georgetown Univ Hosp Dept Med Div Rheumatol Washington DC USA;

Med Univ South Carolina Dept Med Div Rheumatol &

Immunol Charleston SC USA;

Hosp Special Surg Dept Rheumatol 535 E 70th St New York NY 10021 USA;

Johns Hopkins Univ Sch Med Div Rheumatol Baltimore MD USA;

Univ Texas Hlth Sci Ctr Houston Sch Biomed Informat Houston TX 77030 USA;

Univ Texas Hlth Sci Ctr Houston Sch Biomed Informat Houston TX 77030 USA;

Boston Univ Sch Med Dept Microbiol Sect Rheumatol Boston MA 02118 USA;

Boston Univ Sch Med Dept Microbiol Sect Rheumatol Boston MA 02118 USA;

Univ Texas Hlth Sci Ctr Houston Div Rheumatol &

Clin Immunogenet Houston TX 77030 USA;

Boehringer Ingelheim Pharmaceut Inc Ridgefield CT USA;

Boehringer Ingelheim Int GmbH Biberach Germany;

Dartmouth Coll Geisel Sch Med Dept Biomed Data Sci 1 Med Ctr Dr Lebanon NH 03756 USA;

Dartmouth Coll Geisel Sch Med Dept Biomed Data Sci 1 Med Ctr Dr Lebanon NH 03756 USA;

George Washington Univ Sch Med &

Hlth Sci Div Rheumatol Washington DC 20052 USA;

Univ Pittsburgh Sch Med Dept Med Div Rheumatol &

Clin Immunol Pittsburgh PA 15213 USA;

Massachusetts Gen Hosp Div Rheumatol Boston MA 02114 USA;

Vagelos Coll Phys &

Surg Div Rheumatol New York NY USA;

Univ Texas Hlth Sci Ctr Houston Div Rheumatol &

Clin Immunogenet Houston TX 77030 USA;

Univ Texas Hlth Sci Ctr Houston Div Rheumatol &

Clin Immunogenet Houston TX 77030 USA;

Univ Texas Hlth Sci Ctr Houston Div Rheumatol &

Clin Immunogenet Houston TX 77030 USA;

Univ Texas Hlth Sci Ctr Houston Div Rheumatol &

Clin Immunogenet Houston TX 77030 USA;

Univ Texas Hlth Sci Ctr Houston Div Rheumatol &

Clin Immunogenet Houston TX 77030 USA;

Univ Texas Hlth Sci Ctr Houston Div Rheumatol &

Clin Immunogenet Houston TX 77030 USA;

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正文语种 eng
中图分类免疫性疾病;
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专利

1. Global skin gene expression analysis of early diffuse cutaneous systemic sclerosis shows a prominent innate and adaptive inflammatory profile [J] . Skaug Brian, Khanna Dinesh, Swindell William R., Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research . 2020,第3期

机译：早期弥漫性皮肤系统硬化症的全局皮肤基因表达分析显示出突出的天生和适应性炎症性
2. Skin Gene Expression Is Prognostic for the Trajectory of Skin Disease in Patients With Diffuse Cutaneous Systemic Sclerosis [J] . Stifano Giuseppina, Sornasse Thierry, Rice Lisa M., Arthritis & rheumatology. . 2018,第6期

机译：皮肤基因表达是弥漫性皮肤系统硬化症患者皮肤病的轨迹预后
3. Intrinsic gene expression subsets of diffuse cutaneous systemic sclerosis are stable in serial skin biopsies [J] . PendergrassS.A., LemaireR., FrancisI.P., The Journal of investigative dermatology. . 2012,第5期

机译：在一系列皮肤活检中，弥漫性皮肤系统性硬化的内在基因表达子集是稳定的
4. Independent component analysis of gene expression profiles in the hepatic inflammatory response [C] . Nicolini, A.M., Dunn, . 2005

机译：肝炎性反应中基因表达谱的独立成分分析
5. Host response in cutaneous inflammatory disorders: Mechanisms of innate and adaptive immunity. [D] . Kim, Jenny Jiyon. 2001

机译：皮肤炎性疾病中的宿主反应：先天和适应性免疫的机制。
6. Skin gene expression is prognostic for the trajectory of skin disease in patients with diffuse cutaneous systemic sclerosis [O] . Giuseppina Stifano, Thierry Sornasse, Lisa M. Rice, -1

机译：皮肤基因表达可预测弥漫性皮肤系统性硬化症患者的皮肤疾病轨迹
7. Intrinsic Gene Expression Subsets of Diffuse Cutaneous Systemic Sclerosis Are Stable in Serial Skin Biopsies [O] . Pendergrass Sarah A., Lemaire Raphael, Francis Ian P., 2012

机译：弥漫性皮肤系统性硬化的内在基因表达子集在连续的皮肤活检中是稳定的

Global skin gene expression analysis of early diffuse cutaneous systemic sclerosis shows a prominent innate and adaptive inflammatory profile

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