Transethnic meta-analysis identifies GSDMA and PRDM1 as susceptibility genes to systemic sclerosis

Terao Chikashi; Kawaguchi Takahisa; Dieude Philippe; Varga John; Kuwana Masataka; Hudson Marie; Kawaguchi Yasushi; Matucci-Cerinic Marco; Ohmura Koichiro; Riemekasten Gabriela; Kawasaki Aya; Airo Paolo; Horita Tetsuya; Oka Akira; Hachulla Eric; Yoshifuji Hajime; Caramaschi Paola; Hunzelmann Nicolas; Baron Murray; Atsumi Tatsuya; Hassoun Paul; Torii Takeshi; Takahashi Meiko; Tabara Yasuharu; Shimizu Masakazu; Tochimoto Akiko; Ayuzawa Naho; Yanagida Hidetoshi; Furukawa Hiroshi; Tohma Shigeto; Hasegawa Minoru; Fujimoto Manabu; Ishikawa Osamu; Yamamoto Toshiyuki; Goto Daisuke; Asano Yoshihide; Jinnin Masatoshi; Endo Hirahito; Takahashi Hiroki; Takehara Kazuhiko; Sato Shinichi; Ihn Hironobu; Raychaudhuri Soumya; Liao Katherine; Gregersen Peter; Tsuchiya Naoyuki; Riccieri Valeria; Melchers Inga; Valentini Gabriele; Cauvet Anne; Martinez Maria; Mimori Tsuneyo; Matsuda Fumihiko; Allanore Yannick

首页> 外文期刊>Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research >Transethnic meta-analysis identifies GSDMA and PRDM1 as susceptibility genes to systemic sclerosis

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Transethnic meta-analysis identifies GSDMA and PRDM1 as susceptibility genes to systemic sclerosis

机译：转基督荟萃分析将GSDMA和PRDM1识别为系统性硬化的易感性基因

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Objectives Systemic sclerosis (SSc) is an autoimmune disease characterised by skin and systemic fibrosis culminating in organ damage. Previous genetic studies including genome-wide association studies (GWAS) have identified 12 susceptibility loci satisfying genome-wide significance. Transethnic meta-analyses have successfully expanded the list of susceptibility genes and deepened biological insights for other autoimmune diseases.

机译：目的全身硬化（SSC）是一种自身免疫性疾病，其特征在于皮肤和系统性纤维化在器官损伤中。以前的遗传研究包括基因组关联研究（GWAS）已鉴定了满足基因组显着性的12个易感性基因座。转基督的荟萃分析成功扩展了易感性基因列表和对其他自身免疫疾病的加深生物见解。

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《Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research》 |2017年第6期|共9页
作者
Terao Chikashi; Kawaguchi Takahisa; Dieude Philippe; Varga John; Kuwana Masataka; Hudson Marie; Kawaguchi Yasushi; Matucci-Cerinic Marco; Ohmura Koichiro; Riemekasten Gabriela; Kawasaki Aya; Airo Paolo; Horita Tetsuya; Oka Akira; Hachulla Eric; Yoshifuji Hajime; Caramaschi Paola; Hunzelmann Nicolas; Baron Murray; Atsumi Tatsuya; Hassoun Paul; Torii Takeshi; Takahashi Meiko; Tabara Yasuharu; Shimizu Masakazu; Tochimoto Akiko; Ayuzawa Naho; Yanagida Hidetoshi; Furukawa Hiroshi; Tohma Shigeto; Hasegawa Minoru; Fujimoto Manabu; Ishikawa Osamu; Yamamoto Toshiyuki; Goto Daisuke; Asano Yoshihide; Jinnin Masatoshi; Endo Hirahito; Takahashi Hiroki; Takehara Kazuhiko; Sato Shinichi; Ihn Hironobu; Raychaudhuri Soumya; Liao Katherine; Gregersen Peter; Tsuchiya Naoyuki; Riccieri Valeria; Melchers Inga; Valentini Gabriele; Cauvet Anne; Martinez Maria; Mimori Tsuneyo; Matsuda Fumihiko; Allanore Yannick;
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作者单位

Kyoto Univ Grad Sch Med Dept Ctr Genom Med Kyoto Japan;

Kyoto Univ Grad Sch Med Dept Ctr Genom Med Kyoto Japan;

Paris 7 Univ Rheumatol Bichat Hosp Paris France;

Northwestern Univ Feinberg Sch Med Chicago IL 60611 USA;

Keio Univ Sch Med Dept Internal Med Div Rheumatol Tokyo Japan;

Jewish Gen Hosp Montreal PQ Canada;

Tokyo Womens Med Univ Inst Rheumatol Tokyo Japan;

Univ Florence Dept Expt &

Clin Med Dept Med &

Geriatr Med Div Rheumatol AOUC Florence Italy;

Kyoto Univ Grad Sch Med Dept Rheumatol &

Clin Immunol Kyoto Japan;

Univ Lubeck Clin Rheumatol Lubeck Germany;

Univ Tsukuba Fac Med Mol &

Genet Epidemiol Lab Tsukuba Ibaraki Japan;

Spedali Civil Brescia Rheumatol Unit Brescia Italy;

Hokkaido Univ Grad Sch Med Div Rheumatol Endocrinol &

Nephrol Sapporo Hokkaido Japan;

Tokai Univ Inst Med Sci Isehara Kanagawa Japan;

Lille Univ Internal Med Dept FHU Immune Mediated Inflammatory Dis &

Targeted T Lille France;

Kyoto Univ Grad Sch Med Dept Rheumatol &

Clin Immunol Kyoto Japan;

Univ Verona Azienda Osped Univ Integrata Rheumatol Dept Verona Italy;

Univ Cologne Dermatol Dept Cologne Germany;

Jewish Gen Hosp Montreal PQ Canada;

Hokkaido Univ Grad Sch Med Div Rheumatol Endocrinol &

Nephrol Sapporo Hokkaido Japan;

Johns Hopkins Univ Dept Med Div Pulm &

Crit Care Med Baltimore MD USA;

Torii Clin Kyoto Japan;

Kyoto Univ Grad Sch Med Dept Ctr Genom Med Kyoto Japan;

Kyoto Univ Grad Sch Med Dept Ctr Genom Med Kyoto Japan;

Kyoto Univ Grad Sch Med Dept Ctr Genom Med Kyoto Japan;

Tokyo Womens Med Univ Inst Rheumatol Tokyo Japan;

Natl Hosp Org Natl Utano Hosp Dept Rheumatol Kyoto Japan;

Natl Hosp Org Natl Utano Hosp Dept Rheumatol Kyoto Japan;

Univ Tsukuba Fac Med Mol &

Genet Epidemiol Lab Tsukuba Ibaraki Japan;

Natl Hosp Org Sagamihara Hosp Clin Res Ctr Allergy &

Rheumatol Sagamihara Kanagawa Japan;

Univ Fukui Fac Med Sci Dept Dermatol Div Med Fukui Japan;

Univ Tsukuba Fac Med Dept Dermatol Tsukuba Ibaraki Japan;

Gunma Univ Grad Sch Med Dept Dermatol Gunma Japan;

Fukushima Med Univ Dept Dermatol Fukushima Japan;

Univ Tsukuba Fac Med Dept Internal Med Tsukuba Ibaraki Japan;

Univ Tokyo Grad Sch Med Dept Dermatol Tokyo Japan;

Kumamoto Univ Fac Life Sci Dept Dermatol &

Plast Surg Kumamoto Japan;

Toho Univ Sch Med Dept Internal Med Div Rheumatol Tokyo Japan;

Sapporo Med Univ Sch Med Dept Rheumatol &

Clin Immunol Sapporo Hokkaido Japan;

Kanazawa Univ Fac Med Inst Med Pharmaceut &

Hlth Sci Dept Dermatol Kanazawa Ishikawa Japan;

Univ Tokyo Grad Sch Med Dept Dermatol Tokyo Japan;

Brigham &

Womens Hosp Div Rheumatol Allergy &

Immunol Boston MA 02115 USA;

Brigham &

Womens Hosp Div Rheumatol Allergy &

Immunol Boston MA 02115 USA;

Robert S Boas Ctr Genom &

Human Genet Feinstein Inst Med Res Manhasset NY USA;

Univ Tsukuba Fac Med Mol &

Genet Epidemiol Lab Tsukuba Ibaraki Japan;

Sapienza Univ Rome Rome Italy;

Univ Med Ctr Freiburg Germany;

Univ Naples 2 Dept Clin &

Expt Med Rheumatol Sect Naples Italy;

Paris Descartes Univ Cochin Inst INSERM U1016 UMR 8104 Paris France;

Batiment B Purpan Hosp Toulouse INSERM U1220 IRSD Paris France;

Kyoto Univ Grad Sch Med Dept Rheumatol &

Clin Immunol Kyoto Japan;

Kyoto Univ Grad Sch Med Dept Ctr Genom Med Kyoto Japan;

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正文语种 eng
中图分类免疫性疾病;
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专利

1. Transethnic meta-analysis identifies GSDMA and PRDM1 as susceptibility genes to systemic sclerosis [J] . Terao Chikashi, Kawaguchi Takahisa, Dieude Philippe, Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research . 2017,第6期

机译：转基督荟萃分析将GSDMA和PRDM1识别为系统性硬化的易感性基因
2. Common susceptibility loci in both systemic sclerosis and localized scleroderma identified using genetic analysis [J] . Yun Li, Hui-Yao Ge, Dian Chen, 中华医学杂志（英文版） . 2020,第019期

机译：利用遗传分析确定系统性硬化症和局部性硬皮病的常见易感基因座
3. A candidate gene study identifies a haplotype of CD2 as novel susceptibility factor for systemic sclerosis [J] . Koumakis E., Bouaziz M., Dieude P., Clinical and experimental rheumatology . 2016,第5Suppla100期

机译：候选基因研究将CD2的单倍型作为全身硬化症的新易感因子
4. Search for Genetic Factors Associated with Susceptibility to Multiple Sclerosis [C] . GIUSI IRMA FORTE, PAOLO RAGONESE, GIUSEPPE SALEMI, International Association of Biomedical Gerontology International . 2006

机译：搜索与多发性硬化症易感相关的遗传因子
5. Genetic Mapping and Analysis of Disease Susceptibility in a Mouse Model of Multiple Sclerosis [D] . Bearoff, Frank M. 2017

机译：多发性硬化症小鼠模型的遗传图谱和疾病易感性分析
6. Transethnic meta-analysis identifies GSDMA and PRDM1 as susceptibility genes to systemic sclerosis [O] . Chikashi Terao, Takahisa Kawaguchi, Philippe Dieude, 2017

机译：Transethnic meta-analysis将GsDma和pRDm1鉴定为系统性硬化症的易感基因

Transethnic meta-analysis identifies GSDMA and PRDM1 as susceptibility genes to systemic sclerosis

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