Compendium of skin molecular signatures identifies key pathological features associated with fibrosis in systemic sclerosis

Moon Su-Jin; Bae Jung Min; Park Kyung-Su; Tagkopoulos Ilias; Kim Ki-Jo

首页> 外文期刊>Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research >Compendium of skin molecular signatures identifies key pathological features associated with fibrosis in systemic sclerosis

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Compendium of skin molecular signatures identifies key pathological features associated with fibrosis in systemic sclerosis

机译：皮肤分子签名的纲要鉴定了与全身硬化症纤维化相关的关键病理特征

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Objectives Treatment of patients with systemic sclerosis (SSc) can be challenging because of clinical heterogeneity. Integration of genome-scale transcriptomic profiling for patients with SSc can provide insights on patient categorisation and novel drug targets.

机译：由于临床异质性，目标患有系统性硬化症（SSC）的患者的目标可能是挑战性的。用于SSC患者的基因组转录组分析的整合可以提供对患者分类和新型药物靶标的见解。

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《Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research》 |2019年第6期|共9页
作者
Moon Su-Jin; Bae Jung Min; Park Kyung-Su; Tagkopoulos Ilias; Kim Ki-Jo;
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Catholic Univ Korea Coll Med Uijeongbu St Marys Hosp Div Rheumatol Dept Internal Med Seoul;

Catholic Univ Korea Coll Med St Vincents Hosp Dept Dermatol Seoul South Korea;

Catholic Univ Korea Coll Med St Vincents Hosp Div Rheumatol Dept Internal Med Seoul South Korea;

Univ Calif Davis Dept Comp Sci Davis CA 95616 USA;

Catholic Univ Korea Coll Med St Vincents Hosp Div Rheumatol Dept Internal Med Seoul South Korea;

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原文格式 PDF
正文语种 eng
中图分类免疫性疾病;
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1. Compendium of skin molecular signatures identifies key pathological features associated with fibrosis in systemic sclerosis [J] . Moon Su-Jin, Bae Jung Min, Park Kyung-Su, Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research . 2019,第6期

机译：皮肤分子签名的纲要鉴定了与全身硬化症纤维化相关的关键病理特征
2. Molecular characterization of systemic sclerosis esophageal pathology identifies inflammatory and proliferative signatures [J] . Jaclyn N. Taroni, Viktor Martyanov, Chiang-Ching Huang, Arthritis research & therapy. . 2015,第Mara期

机译：系统性硬化食管病理学的分子表征鉴定炎症和增殖性签名
3. Molecular signatures in skin associated with clinical improvement during mycophenolate treatment in systemic sclerosis [J] . HinchcliffM., HuangC.-C., WoodT.A., The Journal of investigative dermatology. . 2013,第8期

机译：霉酚酸酯治疗全身性硬化症期间与临床改善相关的皮肤分子标记
4. Blind spectral unmixing to identify molecular signatures of absorbers in multispectral optoacoustic tomography [C] . Stefan Morscher, Juergen Glatz, Nikolaos C. Deliolanis, Conference on photons plus ultrasound: Imaging and sensing . 2011

机译：盲光谱解混以识别多光谱光声层析成像中吸收体的分子特征
5. Identifying Pathologic and Molecular Features that Predict Adverse Clinical Outcomes in Vulvar Squamous Cell Carcinoma. [D] . Holthoff, Emily Ruth. 2016

机译：鉴定可预测外阴鳞状细胞癌不良临床结果的病理和分子特征。
6. Molecular Signatures in Skin Associated with Clinical Improvement During Mycophenolate Treatment in Systemic Sclerosis [O] . Monique Hinchcliff, Chiang-Ching Huang, Tammara A. Wood, -1

机译：分子签名在皮肤相关的临床改善在治疗霉系统性硬化症
7. ABSTRACT Various body parts or organs can be analysed to identify the different diseases in the human body. Fingernail analysis is one of the ways to identify disease in the human body. Nails are the body part which are farthest from the heart and therefore receive oxygen at last. As a result the nails are the first who show the symptoms of a disease in the human body. Fingernails can be easily captured for diagnosis and there are no heavy equipment or no specific conditions required to use nail image for disease diagnosis, like in other tests and scanning processes. Human nails deliver beneficial information about complaints or any nutritive imbalances in the human body depending upon their shape, texture and colour. In human beings, numerous systemic and skin diseases can be easily analyzed through careful examination of nails of both the limbs. A lot of nail illnesses have been found to be primary signs of numerous underlying systemic illnesses. The colour, texture or shape changes in nails are signs of many diseases mainly affecting nails. Considering all these properties of nails a system is proposed that uses digital image processing (DIP) methods for identifying such changes in the human nail to get more precise results and predict numerous diseases effortlessly. With the emerging Internet of Things (IOT) concept the generated report is made available remotely, this will help users to reduce transportation efforts. As the system has to deal with large and private data, the security of data must be ensured. To keep the data confidential, the Blockchain concept which is one of the most emerging concepts in the field of data management is used. The paper contains the implementation of the digital image processing for feature extraction of nail images, usage of IOT (ThingSpeak cloud) for data storage and implementation of Blockchain to keep the system secured and theft free. KEY WORDS: Int ernet of thin gs (IOT), Image proc essin g, Thin gSpeak, RG B vavalues, Mean pi xel vavalues, Bloc kchain , Hash key. Disease Diagnostic System: Abnormalities in Human Nail [O] . Pranav S. Wazarkar 2020

机译：摘要的各个身体部位或器官可被分析以识别在人体内的不同的疾病。指甲分析来识别人体疾病的方法之一。指甲是身体一部分是离心脏最远，因此在最后接受氧气。作为结果，指甲是第一谁表现出人体疾病的症状。指甲可以容易地捕获用于诊断和没有重装或需要使用指甲图像用于疾病诊断，比如在其他测试和扫描过程没有特定的条件。人的指甲提供有关投诉或取决于它们的形状，纹理和色彩在人体内的任何营养失衡有益的信息。在人类中，许多全身性皮肤疾病是可以很容易地通过两个四肢指甲的仔细检查分析。很多指甲病已发现众多潜在系统性疾病的主要症状。在指甲的颜色，质地和形状的变化是许多疾病主要影响指甲的迹象。考虑到所有的指甲的这些性能的系统被提出，用于识别人指甲这样的变化以获得更精确的结果，并毫不费力预测许多疾病用途的数字图像处理（DIP）方法。随着物联网（IOT）的概念，新兴的互联网将生成的报告提供远程，这将帮助用户降低运输工作。由于系统必须处理大量的私人数据，数据的安全性必须得到保证。为了保持数据的机密性，使用Blockchain的概念，它是在数据管理领域的大多数新兴的概念之一。本文包含了数字图像处理的指甲图像，IOT（ThingSpeak云）的使用为数据存储和执行Blockchain的特征提取的执行，以保持固定的系统和盗窃免费。关键词：诠释薄GS（IOT），图像的ERNET PROC essin克，薄型gSpeak，RG乙vavalues，平均数PI XEL vavalues，阵营kchain，哈希密钥。疾病诊断系统：在人类指甲异常

Compendium of skin molecular signatures identifies key pathological features associated with fibrosis in systemic sclerosis

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