Changes in the reactivity of the immune system of children after the influenza A infection.

摘要

Viruses cause 80-90% of acute respiratory diseases in children (1). Influenza A virus belongs to the most serious etiological agents with significant clinical response of organism. The severity of influenza is a result of the interaction between the virus and the organism, depending on the status of the immune system. Children whose immune system is under the development represent a high-risk group with respect to influenza-mediated complications. The presentation of the virus after the infection triggers release of cytokines and activation of immunologically competent cells (2-4). With the progreding infection the local early immune response continues to the overall response with expression of clinical symptoms. The parameters of humoral and cellular immunity are reflected in laboratory measurable changes (5-5).