Antimicrobial Potential of Alkalophilic Micromycetes Emericellopsis alkalina

摘要

The ability of alkalophilic micromycetes of the Emericellopsis alkalin. to produce antimicrobial peptides has been studied. Evaluation of the spectrum and the yield of antibiotic compounds has allowed us to choose a promising producer of peptide antimycotics, Emericellopsis alkalin A118. The producer exhibits antifungal activity against conditionally pathogenic yeast and mold fungi, i.e., Candida albicans, Aspergillus niger, and A. fumigatus. The group of homologous active compounds isolated by the set of identified structural features (molecular weight, the ratio of the absorption at certain wavelengths, and the absence of initiation of Edman sequencing) may be attributed to peptaibols, which are a group of nonribo-somal membrane-active antimicrobial peptides with a specificity of action primarily against fungi-micromycetes.