Manganese(III) Acetylacetonate-Mediated Phosphorylation of Enamides at Room Temperature

摘要

A highly Z-selective phosphorylation by Manganese(III) acetylacetonate-mediated cross-de-hydrogenative-coupling of enamides and phosphine oxides has been developed under mild conditions. The reaction shows broad substrate scope and functional group compatibility. DFT studies revealed that the formation of Z-products is presumably due to the presence of an intramolecular hydrogen bond. beta-Aminophosphine could be readily obtained by reduction and hydrolysis of the product.