Rhodium(III)-Catalyzed Tandem C-H Olefination and Oxidative Cyclization of Aromatic Acids with Acrylates for the Synthesis of (E)-3-Ylidenephthalides

摘要

Intermolecular tandem C-H olefination/C-O cyclization has been achieved via a rhodium (III)-catalyzed C-H activation of carboxylic acids with acrylates. This strategy provides the direct and efficient construction of biologically relevant (E)-3-ylidenephthalide scaffolds with satisfactory to good yields, and is characterized by stoichiometric reactants, exclusive stereoselectivity, commercially available substrates, mild atmospheric conditions, and short reaction time (less than 2 h).