Chiral N,N '-Dioxide/Sc-III Complex-Catalyzed Asymmetric Ring-Opening Reaction of Cyclopropyl Ketones with Indoles

摘要

The asymmetric ring-opening reaction of cyclopropyl ketones with indoles has been realized by using a N,N'-dioxide/scandium(III) complex as catalyst. The corresponding 3-alkylated indole derivatives were obtained in moderate to excellent yields with good ee values. Moreover, a possible transition state was proposed on the basis of experimental studies and X-ray structure of product.