Protective efficacy of IFN-omega AND IFN-lambda s against influenza viruses in induced A549 cells

摘要

The interferon system represents one of the components of the first line defence against influenza virus infection. Interferon omega (IFN-omega) is antigenetically different from IFN-alpha and IFN-beta and can affect patients who are resistant to these IFNs. To improve the biological characterization of IFN-omega, we compared its activity with those of type land type III IFNs in induced A549 cells. The antiviral effect on IFN-stimulated A549 cells was most apparent after infection with avian influenza virus. IFN-omega had statistically significant antiviral activity although less than IFN-beta 1a, IFN-lambda 1, or IFN-lambda 2. On the other hand, IFN-omega appeared more efficient than IFN-alpha 2. Our results also indicate that IFN-lambda s were more suitable against human highly pathogenic virus. In this case, IFN-lambda 1 and IFN-lambda 2 were more potent than type I IFNs.