Chemo-Enzymatic Dynamic Kinetic Resolution of Amino Acid Thioesters

摘要

The L-forms of racemic-N-protected-beta,gamma-unsaturated alpha-amino acid thioesters were found to be substrates for the subtilisin-eatalysed hydrolysis to the corresponding acids.The D-enantiomer was continuously racemised in the presence of an organ-ic base.The combined reactions in a biphasic system allowed the deracemisation of the amino acid derivatives based on a dynamic kinetic resolu-tion.Excellent yields and enantioselectivities were achieved.