Challenges and Opportunities for Small-Molecule Fluorescent Probes in Redox Biology Applications

Jiang Xiqian; Wang Lingfei; Carroll Shaina L.; Chen Jianwei; Wang Meng C.; Wang Jin

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Challenges and Opportunities for Small-Molecule Fluorescent Probes in Redox Biology Applications

机译：氧化还原生物学应用中小分子荧光探针的挑战和机遇

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Significance: The concentrations of reactive oxygen/nitrogen species (ROS/RNS) are critical to various biochemical processes. Small-molecule fluorescent probes have been widely used to detect and/or quantify ROS/RNS in many redox biology studies and serve as an important complementary to protein-based sensors with unique applications.

机译：意义：反应性氧/氮气（ROS / RNS）的浓度对各种生化过程至关重要。小分子荧光探针已被广泛用于检测和/或量化许多氧化还原生物学研究中的ROS / RN，并用作具有独特应用的基于蛋白质的传感器的重要互补。

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《Antioxidants and redox signalling》 |2018年第6期|共23页
作者
Jiang Xiqian; Wang Lingfei; Carroll Shaina L.; Chen Jianwei; Wang Meng C.; Wang Jin;
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作者单位

Baylor Coll Med Dept Pharmacol &

Chem Biol Houston TX 77030 USA;

Baylor Coll Med Dept Pharmacol &

Chem Biol Houston TX 77030 USA;

Baylor Coll Med Dept Pharmacol &

Chem Biol Houston TX 77030 USA;

Baylor Coll Med Dept Pharmacol &

Chem Biol Houston TX 77030 USA;

Baylor Coll Med Dept Mol &

Human Genet Houston TX 77030 USA;

Baylor Coll Med Dept Pharmacol &

Chem Biol Houston TX 77030 USA;

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原文格式 PDF
正文语种 eng
中图分类基础医学;
关键词
fluorescent probes; sensing and imaging; hydrogen peroxide; glutathione; reversible reactions; ratiometric;

机译：荧光探针;感测和成像;过氧化氢;谷胱甘肽;可逆反应;比例;

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专利

1. Challenges and Opportunities for Small-Molecule Fluorescent Probes in Redox Biology Applications [J] . Jiang Xiqian, Wang Lingfei, Carroll Shaina L., Antioxidants and redox signalling . 2018,第6期

机译：氧化还原生物学应用中小分子荧光探针的挑战和机遇
2. TEMPO-based Redox-sensitive Fluorescent Probes and Their Applications to Evaluating Intracellular Redox Status in Living Cells [J] . Yang Liu, Shanlin Liu, Yanguang Wang Chemistry Letters . 2009,第6期

机译：基于TEMPO的氧化还原敏感荧光探针及其在评估活细胞中细胞内氧化还原状态中的应用
3. Mechanisms and Applications of Redox-Sensitive Green Fluorescent Protein-Based Hydrogen Peroxide Probes [J] . Roma Leticia Prates, Deponte Marcel, Riemer Jan, Antioxidants and redox signalling . 2018,第6期

机译：氧化还原敏感绿色荧光蛋白基过氧化氢探针的机制与应用
4. The Design Principles of Small-molecule Fluorescent Probes for the Detection of Anions [C] . Ran-Ran CHU International Conference on Material Engineering and Application . 2014

机译：小分子荧光探针检测阴离子的设计原理
5. Structural Identification and Applications of Novel Fluorescent Probes in Chemical Biology [D] . Baughman, Brandi M. 2012

机译：新型荧光探针在化学生物学中的结构鉴定与应用
6. Challenges and Opportunities for Small-Molecule Fluorescent Probes in Redox Biology Applications [O] . Xiqian Jiang, Lingfei Wang, Shaina L. Carroll, -1

机译：小分子荧光探针在氧化还原生物学应用中的挑战与机遇
7. Small-Molecule Probe for Sensing Serum Albumin with Consequential Self-Assembly as a Fluorescent Organic Nanoparticle for Bioimaging and Drug-Delivery Applications [O] . -1

机译：用于检测血清白蛋白的小分子探针，其具有相应的自组装作为荧光有机纳米粒子，用于生物分析和药物递送应用
8. N-(3-Pyrene)succinimidothioethanol. A Fluorescent Probe Sensitive to pH and Redox Potential. [R] . Liburdy, R. P. 1977

机译：N-（3-芘）succinimidothioethanol。荧光探针对pH和氧化还原电位敏感。

Challenges and Opportunities for Small-Molecule Fluorescent Probes in Redox Biology Applications

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