Annexin A10 and HES-1 lmmunohistochemistryin Right-sided Traditional Serrated Adenomas Suggestsan Origin From Sessile Serrated Adenoma

摘要

According to the most recent classification by the World Health Organization (WHO), serrated polyps of colon and rectum fall within one of 3 categories: hyperplastic polyp (HP), sessile serrated polyp/adenoma (SSA), and traditional serrated adenoma (TSA). Recent studies have shown that at least a small subset of colonic serrated polyps does not fit into any of these categories. Most of these serrated polyps have morphologic features of traditional serrated adenoma (TSA) admixed with areas resembling sessile serrated adenoma (SSA) or hyperplastic polyp (HP). Prior studies have documented that a significant proportion of TSAs are associated with a component of HP or SSA.1"6 On the basis of these observations it has been suggested that TSAs may arise from nondysplastic precursor lesions including HP and SSAs.