Columnar Cell Lesion and Apocrine Hyperplasia of the Breast: Is There a Common Origin? The Role of Prolactin-induced Protein

摘要

Breast cancer risk indicators, precursors, and non-obligate precursors are part of a complex and heterogeneous group of lesions, which represents a matter of remarkable interest from both clinical and biological standpoints.1 These frequent alterations of the breast range from benign metaplastic changes to high-grade ductal carcinoma in situ (DCIS) and are associated with an increased probability of finding neighboring malignancies.1'2 Their histologic subclassification is usually straightforward and morphology-based.3 However, in a subset of cases, particularly in bioptic samples, the diagnosis might be challenging, given their tight dimensions and overlapping morphologies.2'4'5