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首页> 外文期刊>Anti-cancer agents in medicinal chemistry >In Vitro Inhibitory Effect of Recombinant Human Calprotectin on Nalm6 Leukemia Cell Line
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In Vitro Inhibitory Effect of Recombinant Human Calprotectin on Nalm6 Leukemia Cell Line

机译:重组人类CalProtectin对NALM6白血病细胞系的体外抑制作用

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Background & Purpose: In evaluating new drugs for the treatment of various types of cancer, investigations have been made to discover a variety of anti-tumor compounds with less side effects on normal cells. Investigations have shown that the heterodimers S100A8 and S100A9 inhibit the enzyme casein kinase 2 and then prevent the activation of the E7 oncoprotein. Therefore, the aim of this study was to evaluate the effect of calprotectin as an antitumor compound on the Nalm6 (B cell precursor leukemia cell line).
机译:背景和宗旨:在评估用于治疗各种类型的癌症的新药,已经进行了研究,以发现各种抗肿瘤化合物,对正常细胞的副作用较小。 研究表明,异二聚体S100A8和S100A9抑制酶酪蛋白激酶2,然后防止E7癌蛋白的活化。 因此,本研究的目的是评估CALPROTectin作为NALM6(B细胞前体白血病细胞系)上的抗肿瘤化合物的影响。

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