Effect of Hsp90 Inhibitor KW-2478 on HepG2 Cells

Chang Xiaomin; Zhao Xuerong; Wang Jianping; Ding Shi; Xiao Lijun; Zhao Enhong; Zheng Xin

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Effect of Hsp90 Inhibitor KW-2478 on HepG2 Cells

机译：HSP90抑制剂KW-2478对HepG2细胞的影响

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摘要

Objective: The objectives of this study were to investigate the effects of proliferation, apoptosis, cell cycle, invasion, and senescence of KW-2478 on HepG2 cells, and to explore the related mechanism of apoptosis and the cell cycle.

机译：目的：本研究的目的是探讨KW-2478对HepG2细胞的增殖，凋亡，细胞周期，侵袭和衰老的影响，并探讨细胞凋亡和细胞周期的相关机制。

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来源
《Anti-cancer agents in medicinal chemistry》 |2019年第18期|共12页
作者
Chang Xiaomin; Zhao Xuerong; Wang Jianping; Ding Shi; Xiao Lijun; Zhao Enhong; Zheng Xin;
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作者单位

Chengde Med Univ Dept Immunol Chengde City Hebei Peoples R China;

Chengde Med Univ Dept Immunol Chengde City Hebei Peoples R China;

Chengde Med Univ Dept Immunol Chengde City Hebei Peoples R China;

Chengde Med Univ Dept Pharmacol Chengde City Peoples R China;

Chengde Med Univ Dept Immunol Chengde City Hebei Peoples R China;

Chengde Med Univ Affiliated Hosp Dept Surg 3 Chengde City Peoples R China;

Chengde Med Univ Affiliated Hosp Dept Surg 3 Chengde City Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类药品;
关键词
KW-2478; HepG2; proliferation; apoptosis; cell cycle; invasion; senescence;

机译：KW-2478;hepg2;增殖;细胞凋亡;细胞周期;入侵;衰老;

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专利

1. Effect of Hsp90 Inhibitor KW-2478 on HepG2 Cells [J] . Chang Xiaomin, Zhao Xuerong, Wang Jianping, Anti-cancer agents in medicinal chemistry . 2019,第18期

机译：HSP90抑制剂KW-2478对HepG2细胞的影响
2. Geldanamycin, an inhibitor of Hsp90 increases cytochrome P450 2E1 mediated toxicity in HepG2 cells through sustained activation of the p38MAPK pathway [J] . Dey A, Cederbaum AI Archives of Biochemistry and Biophysics . 2007,第2期

机译：格尔德霉素（一种Hsp90抑制剂）通过持续激活p38MAPK途径增加HepG2细胞中细胞色素P450 2E1介导的毒性
3. Geldanamycin,an Inhibitor of Hsp90,Potentiates Cytochrome P4502E1-Mediated Toxicity in HepG2 Cells [J] . Aparajita Dey, Arthur I.Cederbaum The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 2006,第3期

机译：格尔德霉素，一种Hsp90抑制剂，可增强细胞色素P4502E1介导的HepG2细胞毒性。
4. The F protein of Hepatitis C virus subtype 1b inhibits human hepatocellular carcinom HepG2 cell apoptosis in vitro [C] . Yang Jing-Jing, Zhang Yun, Deng Xiao-Zhao, International Symposium on Medical and Pharmaceutical Biotechnology(医药生物技术国际研讨会) . 2009

机译：丙型肝炎病毒1b亚型的F蛋白在体外抑制人肝癌细胞HepG2细胞凋亡
5. Radiosensibilisierung Humaner Tumorzelllinien Unterschiedlicher Entit?ten Durch Den MEK-Inhibitor PD184352 Allein Oder in Kombination mit dem HSP90-Inhibitor NVP-AUY922: Einfluss der Behandlungsschemas =Radiosensitization of Human Tumor Cell Lines of Diff [D] . Grabenbauer, Felix. 2021

机译：单独的MEK抑制剂PD184352或与HSP90抑制剂NVP-AUY922组合的不同实体的人肿瘤细胞系的放射敏化：治疗方案的影响=差异的人肿瘤细胞系的放射敏感性
6. Phase I study of KW-2478 a novel Hsp90 inhibitor in patients with B-cell malignancies [O] . K Yong, J Cavet, P Johnson, 2016

机译：新型Hsp90抑制剂KW-2478在B细胞恶性肿瘤患者中的I期研究
7. Phase I study of KW-2478, a novel Hsp90 inhibitor, in patients with B-cell malignancies [O] . Yong, K., Cavet, J., Johnson, P., 2016

机译：第一阶段研究KW-2478，一种新型Hsp90抑制剂，用于B细胞恶性肿瘤患者

Effect of Hsp90 Inhibitor KW-2478 on HepG2 Cells

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