Latest Evidence on the Role of Multiparametric Magnetic Resonance Imaging in Active Surveillance for Insignificant Prostate Cancer: A Systematic Review

摘要

Objective: Multiparametric Magnetic Resonance Imaging (mpMRI) has become a very useful tool inthe management of PCa. Particularly, there is a great interest in using mpMRI for men on Active Surveillance(AS) for low risk PCa. The aim of this systematic review was to critically review the latest literature concerningthe role of mpMRI in this clinical setting, underlying current strengths and weakness.Evidence Acquisition: A comprehensive literature research for English-language original and review articleswas carried out using the National Center for Biotechnology Information PubMed database with the aim toidentify studies pertaining to mpMRI for AS in low risk PCa patients. The following search terms were used:active surveillance, prostate cancer and multiparametric magnetic resonance imaging.Evidence Synthesis: Data from 28 recent original studies and reviews were reviewed. We only considered studieson the use of mpMRI in selecting AS patients and during AS follow-up, in order to solve two importantquestions: -Can mpMRI have a role in improving the detection of clinically significant disease, better selectingAS patients? -Can mpMRI identify the progression of disease and, consequently, be used during AS follow-up?Conclusions: mpMRI is useful to better select the ideal candidates to AS and to monitor them during follow-up.However, despite many advantages, there are yet important limitations to detect all clinically significant PCaand to better define mpMRI-radiological progression during AS. Further larger prospective studies are needed todefinitively solve these important problems.