Aminotransferase levels, body mass index, and the risk of diabetes: a?prospective cohort study

摘要

PurposeTo investigate whether the relationship between body mass index (BMI) and incident diabetes is modified by different alanine or aspartate aminotransferases (ALT or AST) levels. MethodsWe carried out an analysis of 6484 participants aged 40?years or older using data from the Korean Genome Epidemiology Study. The serum aminotransferase levels were stratified into low and high groups according to the median values and classified into three groups: both low, either high, and both high. To assess the association between BMI and incident diabetes according to the serum aminotransferase levels, multiple logistic regression models were used. ResultsIn participants with high levels of both ALT and AST, compared with the first BMI quartile, the adjusted odds ratios for incident diabetes of the second, third, and fourth BMI quartiles were 1.72 (95% confidence interval, 0.84–3.55), 2.19 (1.11–4.33), and 3.08 (1.60–5.90), respectively (Ptrend?