Malaria control: a genetically engineered fungus that kills Anopheles mosquitoes

摘要

With more than 200 million cases per year and causing an estimated 10.2 deaths per 100,000 people worldwide (GBD 2016 Causes of Death Collaborators, 2017}, malaria, caused by apicomplexan parasites of the genus Plasmodium and transmitted by adult female anopheline mosquitoes, is the world's most deadly vector-borne human disease. Sub-Saharan Africa is by far the worst hit region, and more than 90% of global malaria cases occur there (WHO, 2018). A massive US$ 4.3 billion was invested globally in malaria control and elimination efforts in 2016 alone (Haakenstad et al, 2019).