Inflammatory Response Modulation through a PPAR gamma Agonist during Surgically Induced Visceral Ischemia in an Animal Model

摘要

Background: Ischemia/reperfusion (I/R) injury represents one of the most severe complications in vascular surgery where cross-clamping of the aorta and subsequent visceral ischemia are a recurrent issue. The literature describes a family of nuclear receptors, that is, peroxisome proliferator-activated receptors (PPARs), in particular PPAR gamma isoform, which are important modulators of vascular inflammation resulting from I/R injury. The aim of our study is to evaluate how PPAR gamma agonist administration could reduce local and systemic inflammatory response after I/R injury during aortic supraceliac clamping in animal model.