Testosterone replacement therapy improves health-related quality of life for patients with late-onset hypogonadism: a meta-analysis of randomized controlled trials

摘要

Although testosterone replacement therapy can restore serum testosterone concentrations to normal level in late-onset hypogonadism patients, whether it can improve patients' quality of life remains uncertain. Therefore, we perform a meta-analysis of randomized controlled trials on this issue. Five randomized controlled trials total 1,212 patients were included. Fixed-effect model was used to calculate the weighted mean difference of score of Aging Males' Symptom rating scale. Our result reveals that testosterone replacement therapy improves patients' health-related quality of life in terms of the decrease in the AMS total score [WMD=-2.96 (-4.21, -1.71), p<.00001] and the psychological [WMD=-0.89 (-1.41, -0.37), p=.0008], somatic [WMD=-0.89 (-1.41, -0.37), p=.0008] and sexual [WMD=-1.29 (-1.75, -0.83), p<.00001] subscale score.