The severity of obstructive sleep apnea syndrome cannot predict the accumulation of brain amyloid by imaging with [11C]-Pittsburgh compound B PET computed tomography in patients with a normal cognitive function

摘要

ObjectiveDisturbed sleep due to obstructive sleep apnea syndrome (OSAS) might accelerate amyloid beta (A beta) deposition, which can be a crucial factor in Alzheimer's disease. We studied A beta deposition in untreated OSAS patients with normal cognition.MethodWe performed polysomnography (PSG) and A beta imaging with [C-11]-Pittsburgh compound B PET computed tomography (C-11-PiB PET CT) in 14 untreated OSAS patients (apnea-hypopnea index: 43.826.3/h).ResultsThe abnormal accumulation of enhanced C-11-PiB PET was observed only one patient with severe, but not the most severe.Conclusions The OSAS severity alone may not predict A beta deposition in OSAS patients with normal cognition.