Changes in chronic rhinosinusitis symptoms differentially associate with improvement in general health-related quality of life

摘要

BackgroundPrevious work has shown that the symptoms of chronic rhinosinusitis (CRS) differentially associate with decreased general health-related quality of life (QOL). ObjectiveWe sought to determine whether longitudinal changes in different types of CRS symptomatology lead to correspondingly different magnitude changes in general health-related QOL. MethodsProspective observational study of 145 patients undergoing medical management for CRS. Chronic rhinosinusitis symptom severity was measured using the 22-item Sinonasal Outcome Test (SNOT-22) and associated nasal, sleep, ear/facial discomfort, and emotional subdomains of the SNOT-22. General health-related QOL was measured using the 5-dimensional EuroQoL questionnaire's visual analog scale (EQ-5D VAS). These data were collected at 2 time points: at enrollment and at a subsequent follow-up visit within the next 2 to 6 months. Associations were sought between the changes in SNOT-22 and EQ-5D VAS. ResultsThe change in SNOT-22 was associated with change in EQ-5D VAS (adjusted linear regression coefficient [β]?=??0.37, 95%CI: ?0.51 to ?0.24,P?