Determination of Levodopa in Pharmaceuticals Using a Disposable Electrochemically Activated Carbon-Paste Electrode by Linear Sweep Voltammetry

摘要

A simple disposable electrochemically activated carbon-paste electrode was developed for the determination of levodopa in pharmaceuticals and the optimal conditions for carbon-paste electrode electrochemical activation were studied. The study of the oxidation process of levodopa on the proposed electrode was performed using cyclic voltammetry and the irreversibility of levodopa with a kinetic-controlled current was established. The determination of levodopa is possible in the concentration range of 5-100 mu M. The detection and quantification limits were 0.65 and 0.79 mu M, respectively. The proposed procedure was satisfactorily applied in the levodopa determination in pharmaceuticals with relative standard deviation 3.4%.