Effects of gamma-Aminobutyric Acid Type A Receptor Modulation by Flumazenil on Emergence from General Anesthesia

摘要

Background: Transitions into conscious states are partially mediated by inactivation of sleep networks and activation of arousal networks. Pharmacologic hastening of emergence from general anesthesia has largely focused on activating subcortical monoaminergic networks, with little attention on antagonizing the.-aminobutyric acid type A receptor (GABA(A)R). As the GABA(A)R mediates the clinical effects of many common general anesthetics, the authors hypothesized that negative GABA(A)R modulators would hasten emergence, possibly via cortical networks involved in sleep.