Characterization of Clostridium difficile isolates collected during a phase 2b clinical study with SYN-004 (ribaxamase) for the prevention of C. difficile infection

Kokai-Kun John E.; Sarver J. Lauren; Carman Robert J.

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Characterization of Clostridium difficile isolates collected during a phase 2b clinical study with SYN-004 (ribaxamase) for the prevention of C. difficile infection

机译：在2B型临床研究中与Syn-004（核碱基）预防C.艰难梭菌性感染期间收集的梭菌艰难梭菌分离物的表征

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During a Phase 2b study with SYN-004 (ribaxamase) for prevention of Clostridium difficile infection (CDI) conducted in North America and Eastern Europe, 45 C. difficile isolates from subjects with laboratory-confirmed CDI and or colonized with C. difficile were collected and characterized. Several C. difficile PCR ribotypes, including 027 and 198, were identified. (C) 2018 Elsevier Ltd. All rights reserved.

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《Anaerobe》 |2018年第2018期|共4页
作者
Kokai-Kun John E.; Sarver J. Lauren; Carman Robert J.;
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作者单位

Synthet Biol Inc Rockville MD USA;

TechLab Inc Blacksburg VA USA;

TechLab Inc Blacksburg VA USA;

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原文格式 PDF
正文语种 eng
中图分类微生物学;
关键词
Clostridium difficile infection; PCR ribotyping; Clinical isolates;

机译：Clostridium艰难的感染;PCR核糖型;临床分离株;

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1. Characterization of Clostridium difficile isolates collected during a phase 2b clinical study with SYN-004 (ribaxamase) for the prevention of C. difficile infection [J] . Kokai-Kun John E., Sarver J. Lauren, Carman Robert J. Anaerobe . 2018,第期

机译：在2B型临床研究中与Syn-004（核碱基）预防C.艰难梭菌性感染期间收集的梭菌艰难梭菌分离物的表征
2. Tolerability and Pharmacokinetics of SYN-004, an Orally Administered beta-Lactamase for the Prevention of Clostridium difficile-Associated Disease and Antibiotic-Associated Diarrhea, in Two Phase 1 Studies [J] . Roberts Tracey, Kokai-Kun John F., Coughlin Olivia, Clinical drug investigation . 2016,第9期

机译：SYN-004的耐受性和药代动力学，这是一种口服β-内酰胺酶，用于预防艰难梭菌相关疾病和抗生素相关性腹泻，目前处于两项1期研究中
3. Susceptibility of Clostridium difficile isolates from a Phase 2 clinical trial of cadazolid and vancomycin in C-difficile infection [J] . Gerding D. N., Hecht D. W., Louie T., The Journal of Antimicrobial Chemotherapy . 2016,第1期

机译：cadazolid和万古霉素2期临床试验中难辨梭状芽孢杆菌分离物在C难辨性感染中的敏感性
4. Molecular characterization and evaluation of Clostridium difficile field isolates recovered from pigs with neonatal diarrhea [C] . Boh Chang Lin, Steve Heller, Leann Siedlik, Annual Meeting of the American Association of Swine Veterinarians . 2009

机译：用新生儿腹泻从猪回收的梭菌差异场分离物的分子表征和评价
5. Experimental Clostridium difficile enterocolitis in foals and molecular typing of C. difficile isolates originating from different species and a teaching hospital environment. [D] . Arroyo Castro, Luis G. 2004

机译：驹中的实验性艰难梭菌小肠结肠炎和源自不同物种和教学医院环境的艰难梭菌分离物的分子分型。
6. SYN-004 (ribaxamase) prevents New Onset Clostridium difficile Infection by Protecting the Integrity Gut Microbiome in a Phase 2b Study [O] . John Kokai-Kun, Tracey Roberts, Olivia Coughlin, 2017

机译：在2b期研究中SYN-004（核糖酰胺酶）通过保护完整性肠道微生物组来预防新的难辨梭状芽胞杆菌感染。
7. SYN-004 (ribaxamase) prevents New Onset Clostridium difficile Infection by Protecting the Integrity Gut Microbiome in a Phase 2b Study [O] . John Kokai-Kun, Tracey Roberts, Olivia Coughlin, 2017

机译：SYN-004（Ribaxamase）通过在第2B期研究中保护完整性肠道微生物组来防止新的发病梭菌感染
8. Evaluation and Research on Antimicrobial Stewardship's Effect on Clostridium difficile (ERASE C. difficile) Project. Toolkit for Reduction of Clostridium difficile through Antimicrobial Stewardship. [R] . 2012

机译：抗菌药物管理对艰难梭菌（ERasE C. difficile）项目影响的评价与研究。通过抗菌药物管理减少艰难梭菌的工具包。

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Characterization of Clostridium difficile isolates collected during a phase 2b clinical study with SYN-004 (ribaxamase) for the prevention of C. difficile infection

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