Effect of different surfactants on the release pattern of cocoa butter suppositories containing Flurbiprofen sodium

摘要

Suppositories were formulated by hot melting / fusion method and evaluated for their physicochemical characterization followed by in vitro evaluation. The present investigation was aimed to evaluating the possibility of using suppository base i.e. cocoa butter with different surfactants i.e. SLS, Span 60 and 80, Tween 60 and 80 and sodium taurocholate for the development of rectal drug delivery system of flurbiprofen sodium, an NSAIDs, to minimize the gastric irritation of the drug upon oral administration. Suppositories containing PEG 4000 with SLS showed a better permeation of drug with faster dissolution rate in vitro than other formulations.