Biofunctional Beverage: Antihyperglycemic Effect of Green Tea in Alloxan Induced Diabetic Rabbits

摘要

Background: Diabetes is a chronic metabolic syndrome that affecting millions of peoplearound the world. There are several therapeutic options for the treatment of diabetes but adequate glycemiccontrol is still a challenge. In this regard, daily food item has been focus to evaluate their effecton blood glucose control.Methods: Our study investigated the effect of oral consumption of crude extract and its subsequentsolvent fractions (hexane, ethyl acetate and aqueous) of Green Tea purchased from local market in alloxan-induced diabetic rabbits. Plasma glucose level and overall affect on body weight was observed ondaily basis up t 26th day at 25 and 50 mg/kg p.o.Results: The results showed significant (P<0.05) reduction in hyperglycemia-induced in rabbits. Thecrude extract was most dominant in its effect after 26th of administration, while hexane fraction did notproduce any antihyperglycemic effect. However, the remaining fractions elicited moderate effects.When the effect of these extracts were studied on body weight of diabetic rabbits, marked recovery inbody weight was observed.Conclusion: In short, it is concluded, that the various extracts of green tea possessed strong antidiabeticand weight regaining effects in alloxan-induced diabetic rabbits, and thus appeared as a significant biofunctionalfood in diabetes management. Furthermore, bioactivity guided isolation of secondary metabolitescould provide chemical background.