BMS-986163, a Negative Allosteric Modulator of GluN2B with Potential Utility in Major Depressive Disorder

著录项

• 来源
  《ACS medicinal chemistry letters》 |2018年第5期|共6页
• 作者

  Lawrence R. Marcin; Jayakumar Warrier; Srinivasan Thangathirupathy; Jianliang Shi; George N. Karageorge; Bradley C. Pearce; Alicia Ng; Hyunsoo Park; James Kempson; Jianqing Li; Huiping Zhang; Arvind Mathur; Aliphedi B. Reddy; G. Nagaraju; Gopikishan Tonukunuru; Grandhi V. R.K. M. Gupta; Manjunatha Kamble; Raju Mannoori; Srinivas Cheruku; Srinivas Jogi; Jyoti Gulia; Tanmaya Bastia; Charulatha Sanmathi; Jayant Aher; Rajareddy Kallem; Bettadapura N. Srikumar; Kumar Kuchibhotla Vijaya; Pattipati S. Naidu; Mahesh Paschapur; Narasimharaju Kalidindi; Reeba Vikramadithyan; Manjunath Ramarao; Rex Denton; Thaddeus Molski; Eric Shields; Murali Subramanian; Xiaoliang Zhuo; Michelle Nophsker; Jean Simmermacher; Michael Sinz; Charlie Albright; Linda J. Bristow; Imadul Islam; Joanne J. Bronson; Richard E. Olson; Dalton King; Lorin A. Thompson; John E. Macor;

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• 作者单位

  Bristol-Myers Squibb Research and Development 5 Research Parkway Wallingford Connecticut 06492 United States;

  Biocon Bristol-Myers Squibb Research Center Bangalore India;

  Biocon Bristol-Myers Squibb Research Center Bangalore India;

  Bristol-Myers Squibb Research and Development 3551 Lawrenceville Road Princeton New Jersey 08648 United States;

  Bristol-Myers Squibb Research and Development 5 Research Parkway Wallingford Connecticut 06492 United States;

  Bristol-Myers Squibb Research and Development 5 Research Parkway Wallingford Connecticut 06492 United States;

  Bristol-Myers Squibb Research and Development 5 Research Parkway Wallingford Connecticut 06492 United States;

  Bristol-Myers Squibb Research and Development 3551 Lawrenceville Road Princeton New Jersey 08648 United States;

  Bristol-Myers Squibb Research and Development 3551 Lawrenceville Road Princeton New Jersey 08648 United States;

  Bristol-Myers Squibb Research and Development 3551 Lawrenceville Road Princeton New Jersey 08648 United States;

  Bristol-Myers Squibb Research and Development 3551 Lawrenceville Road Princeton New Jersey 08648 United States;

  Bristol-Myers Squibb Research and Development 3551 Lawrenceville Road Princeton New Jersey 08648 United States;

  Biocon Bristol-Myers Squibb Research Center Bangalore India;

  Biocon Bristol-Myers Squibb Research Center Bangalore India;

  Biocon Bristol-Myers Squibb Research Center Bangalore India;

  Biocon Bristol-Myers Squibb Research Center Bangalore India;

  Biocon Bristol-Myers Squibb Research Center Bangalore India;

  Biocon Bristol-Myers Squibb Research Center Bangalore India;

  Biocon Bristol-Myers Squibb Research Center Bangalore India;

  Biocon Bristol-Myers Squibb Research Center Bangalore India;

  Biocon Bristol-Myers Squibb Research Center Bangalore India;

  Biocon Bristol-Myers Squibb Research Center Bangalore India;

  Biocon Bristol-Myers Squibb Research Center Bangalore India;

  Biocon Bristol-Myers Squibb Research Center Bangalore India;

  Biocon Bristol-Myers Squibb Research Center Bangalore India;

  Biocon Bristol-Myers Squibb Research Center Bangalore India;

  Biocon Bristol-Myers Squibb Research Center Bangalore India;

  Biocon Bristol-Myers Squibb Research Center Bangalore India;

  Biocon Bristol-Myers Squibb Research Center Bangalore India;

  Biocon Bristol-Myers Squibb Research Center Bangalore India;

  Biocon Bristol-Myers Squibb Research Center Bangalore India;

  Biocon Bristol-Myers Squibb Research Center Bangalore India;

  Bristol-Myers Squibb Research and Development 3551 Lawrenceville Road Princeton New Jersey 08648 United States;

  Bristol-Myers Squibb Research and Development 5 Research Parkway Wallingford Connecticut 06492 United States;

  Bristol-Myers Squibb Research and Development 5 Research Parkway Wallingford Connecticut 06492 United States;

  Biocon Bristol-Myers Squibb Research Center Bangalore India;

  Bristol-Myers Squibb Research and Development 5 Research Parkway Wallingford Connecticut 06492 United States;

  Bristol-Myers Squibb Research and Development 5 Research Parkway Wallingford Connecticut 06492 United States;

  Bristol-Myers Squibb Research and Development 5 Research Parkway Wallingford Connecticut 06492 United States;

  Biocon Bristol-Myers Squibb Research Center Bangalore India;

  Bristol-Myers Squibb Research and Development 5 Research Parkway Wallingford Connecticut 06492 United States;

  Bristol-Myers Squibb Research and Development 5 Research Parkway Wallingford Connecticut 06492 United States;

  Biocon Bristol-Myers Squibb Research Center Bangalore India;

  Bristol-Myers Squibb Research and Development 5 Research Parkway Wallingford Connecticut 06492 United States;

  Bristol-Myers Squibb Research and Development 5 Research Parkway Wallingford Connecticut 06492 United States;

  Bristol-Myers Squibb Research and Development 5 Research Parkway Wallingford Connecticut 06492 United States;

  Bristol-Myers Squibb Research and Development 5 Research Parkway Wallingford Connecticut 06492 United States;

  Bristol-Myers Squibb Research and Development 5 Research Parkway Wallingford Connecticut 06492 United States;

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• 收录信息
• 原文格式 PDF
• 正文语种 eng
• 中图分类 药学;化学;
• 关键词

  BMS-986163; BMS-986169; depression; GluN2B; ketamine; negative allosteric modulator; preclinical candidate;

  机译：BMS-986163;BMS-986169;抑郁症;GLUN2B;氯胺酮;负变性调节剂;临床前候选人;