Qualitative and quantitative analysis of three amino acid derivatives of anticonvulsant activity.

摘要

Qualitative and quantitative methods of analysis of three new amino-acid derivatives potential anticonvulsants of low neurotoxicity: picolinic acid benzylamide (1), nicotinic acid benzylamide (2) and isonicotinic acid benzylamide (3) were developed. Qualitative analysis includes characteristic reactions, chromatographic (TLC) investigations, IR and UV spectra interpretation. The quantitative analysis involves spectophotometric, chromatographic (HPLC) and acidimetric methods.