Effect of amantadine in minimally conscious state of non-traumatic etiology

摘要

Amantadine is a dopaminergic agonist that has been recently used in patients with post-traumatic disorder of consciousness (DOC) due to its efficacy and safe profile with few secondary effects [2-4, 12]. Amantadine treatment has demonstrated acceleration of functional recovery in patients with post-traumatic DOC [6]. However, there is a lack of studies evaluating amantadine in the treatment of non-traumatic DOC [9, 12, 13].