A Focus on Replacement

摘要

FRAME'S ultimate aim is the elimination of the need to use laboratory animals in any kind of medical or scientific procedures — with the full name of the charity being Fund for the Replacement of Animals in Medical Experiments. Of the Three Rs principles described by Russell and Burch in their 1959 book, The Principles of Humane Experimental Technique,1 replacement is undoubtedly the most important (and perhaps the most difficult) of the Three Rs to implement in practice, over the other two 'Rs' — reduction and refinement.