Neuropsychological outcome after extra-temporal epilepsy surgery

摘要

Background The neuropsychological results of temporal lobe epilepsy surgery are well reported in the literature. The aim of this study was to analyse the neuropsychological outcome in a consecutive series of patients with extratemporal epilepsy. Methods We retrospectively analysed the data of patients operated between 1996 and 2008 for extra-temporal epilepsy. Standard neuropsychological tests were applied. We assessed the neuropsychological outcome after surgery and the correlation of the neuropsychological outcome with (1) side and localisation of surgery, (2) Engel scale for seizure outcome and (3) timing of surgery. Findings Patients had a better neuropsychological outcome when undergoing non-frontal resection [?2 (2) 06.66, p00.036]. Subjects who had undergone left or right resection showed no difference in outcome [?2 (2) 00.533, p00.766]. The correlation between the Engel scale for seizure reoccurence and the neuropsychological scores showed only a tendency for better outcome (Spearman ρ0-0.437; p00.069). The global measure of change did not correlate significantly with delay of surgery (Spearman ρ0-0.163; p00.518). Conclusions Resective epilepsy surgery improves neuropsychological status outcome in patients with extratemporal epilepsy even if the patient did not become seizure free. The outcome is better for non-frontal localisation.