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Genome‐wide SNP typing of ancient DNA: Determination of hair and eye color of Bronze Age humans from their skeletal remains

机译：古代DNA的基因组SNP键入：核心遗骸的青铜时期人类的头发和眼睛

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Abstract <section xml:id="ajpa23996-sec-0001" numbered="no"> <title type="main">Objective >A genome‐wide high‐throughput single nucleotide polymorphism (SNP) typing method was tested with respect of the applicability to ancient and degraded DNA. The results were compared to mini‐sequencing data achieved through single base extension (SBE) typing. The SNPs chosen for the study allow to determine the hair colors and eye colors of humans. </section> <section xml:id="ajpa23996-sec-0002" numbered="no"> <title type="main">Material and methods >The DNA samples were extracted from the skeletal remains of 59 human individuals dating back to the Late Bronze Age. The 3,000?years old bones had been discovered in the Lichtenstein Cave in Lower Saxony, Germany. The simultaneous typing of 24 SNPs for each of the ancient DNA samples was carried out using the 192.24 Dynamic Array? by Fluidigm?. </section> <section xml:id="ajpa23996-sec-0003" numbered="no"> <title type="main">Results >Thirty‐eight of the ancient samples (=64%) revealed full and reproducible SNP genotypes allowing hair and eye color phenotyping. In 10 samples (=17%) at least half of the SNPs were unambiguously determined, in 11 samples (=19%) the SNP typing failed. For 23 of the 59 individuals, a comparison of the SNP typing results with genotypes from an earlier performed SBE typing approach was possible. The comparison confirmed the full concordance of the results for 90% of the SNP typings. In the remaining 10% allelic dropouts were identified. </section> <section xml:id="ajpa23996-sec-0004" numbered="no"> <title type="main">Discussion >The high genotyping success rate could be achieved by introducing modifications to the preamplification protocol mainly by increasing the DNA input and the amplification cycle number. The occurrence of allelic dropouts indicates that a further increase of DNA input to the preamplification step is desirable. </section> </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> <第XML：ID =“AJPA23996-SEC-0001”编号=“否”> <标题类型=“main”>目标</ title> >关于适用于古老和降解的DNA的适用性测试了基因组高通量单核苷酸多态性（SNP）键入方法。将结果与通过单个基本延伸（SBE）键入实现的迷你测序数据进行比较。选择该研究的SNP允许确定人类的头发颜色和眼睛。</ p> </部分> <第XML：ID =“AJPA23996-SEC-0002”编号=“否”> <标题类型=“main”>素材和方法</ title> > DNA样品从59例人体的骨骼剩余物中提取，其追溯到后期青铜时代。德国下萨克森州的利德斯坦洞穴发现了3,000岁的骨头。使用192.24动态阵列进行每种古代DNA样本的同时打字24个SNPS？通过液体？</ p> </部分> <第XML：ID =“AJPA23996-SEC-0003”编号=“否”> <标题类型=“main”>结果</ title> 古代样品（= 64％）允许头发和眼睛颜色表型的全部和可重复的SNP基因型透露出允许头发和眼睛颜色表型的全部和可重复的SNP基因型。在10个样品中（= 17％）在11个样本（= 19％）中，SNP打字失败的11个样品中，至少一半的SNP毫不含糊地确定。对于59个个体中的23个，可以比较SNP键入结果与早期的基因型进行的SBE键入方法是可能的。比较证实了90％的SNP打字结果的全面协调。在剩余的10％的等位基因辍学中被识别出来。</ p> </部分> <第XML：ID =“AJPA23996-SEC-0004”编号=“否”> <标题类型=“main”>讨论</ title> 通过增加DNA输入和放大循环数来引入前置放大方案的修饰来实现高基因分型成功率。等位基因丢失的发生表明，需要进一步增加对前置放大步骤的DNA。</ p> </部分> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-18756/'>《American Journal of Physical Anthropology》</a> <b style="margin: 0 2px;">|</b><span>2020年第1期</span><b style="margin: 0 2px;">|</b><span>共11页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Schmidt Nicole&option=202" target="_blank" rel="nofollow">Schmidt Nicole;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Schücker Katharina&option=202" target="_blank" rel="nofollow">Schücker Katharina;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Krause Ina&option=202" target="_blank" rel="nofollow">Krause Ina;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=D?rk Thilo&option=202" target="_blank" rel="nofollow">D?rk Thilo;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Klintschar Michael&option=202" target="_blank" rel="nofollow">Klintschar Michael;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hummel Susanne&option=202" target="_blank" rel="nofollow">Hummel Susanne;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of Historical Anthropology and Human EcologyUniversity of G?ttingenG?ttingen Germany;</p> <p>Department of Historical Anthropology and Human EcologyUniversity of G?ttingenG?ttingen Germany;</p> <p>Department of Historical Anthropology and Human EcologyUniversity of G?ttingenG?ttingen Germany;</p> <p>Gynaecological Research UnitHannover Medical SchoolHannover Germany;</p> <p>Hannover Medical SchoolInstitute for Legal MedicineHannover Germany;</p> <p>Department of Historical Anthropology and Human EcologyUniversity of G?ttingenG?ttingen Germany;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/187.html" title="人类学">人类学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=ancient and degraded DNA&option=203" rel="nofollow">ancient and degraded DNA;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=eye color&option=203" rel="nofollow">eye color;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=genome wide&option=203" rel="nofollow">genome wide;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=hair color&option=203" rel="nofollow">hair color;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=high‐throughput SNP typing&option=203" rel="nofollow">high‐throughput SNP typing;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=phenotype&option=203" rel="nofollow">phenotype;</a> </p> <div class="translation"> 机译：古老和降解的DNA;眼睛颜色;基因组宽;发色;高通量SNP打字;表型; </div> </li> <li> <span class="lefttit">入库时间</span> <span>2022-08-20 00:50:32</span> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704022536141.html">Genome‐wide SNP typing of ancient DNA: Determination of hair and eye color of Bronze Age humans from their skeletal remains</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Schmidt Nicole&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Schmidt 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A.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext= Soto, A.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> Soto, A.,</a> <span>2011</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：军事工作犬智力的全基因组关联图谱：犬群，犬智力评估方案，全基因组单核苷酸多态性（sNp）分型和无监督分类算法的全基因组关联数据分析</span> </p> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/academic-journal-cn_journal-tongling-vocational-technical-college_thesis/0201269880220.html">简述先秦时期青铜文化与古代人类文明的关系</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=常雪&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 常雪</a> <span> <a href="/journal-cn-3759/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 铜陵职业技术学院学报 </a> </span> <span> . 2018</span><span>,第003期</span> </span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-cn_detail_thesis/0201293730544.html">人类基因组多样性(HGD)与人类基因组多样性计划(HGDP)(2) DNA、RNA和蛋白质研究的有关资料</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . </a> <span> <a href="/journal-cn-57495/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 现代临床医学生物工程学杂志 </a> </span> <span> . 2003</span><span>,第1期</span> </span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-journal-cn_life-science-research_thesis/0201297967308.html">古DNA技术在人类墓葬遗骸研究中的应用及进展</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=孙辉&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 孙辉</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=阳小成&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,阳小成</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=李璟&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,李璟</a> <span> <a href="/journal-cn-5069/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 生命科学研究 </a> </span> <span> . 2005</span><span>,第S1期</span> </span> </div> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-journal-cn_earth-science-journal-china-university-geosciences_thesis/0201297472498.html">仰韶文化人类遗骸古DNA的初步研究</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=赖旭龙&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 赖旭龙</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=杨淑娟&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,杨淑娟</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=唐先华&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,唐先华</a> <span> <a href="/journal-cn-50713/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 地球科学：中国地质大学学报 </a> </span> <span> . 2004</span><span>,第1期</span> </span> </div> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-journal-cn_guizhou-culture-history_thesis/0201227720866.html">夜郎研究的途径之一--势在必行的贵州古人类遗骸DNA研究</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=曹波&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 曹波</a> <span> <a href="/journal-cn-1486/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 贵州文史丛刊 </a> </span> <span> . 2003</span><span>,第001期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-8133_thesis/020222084513.html">近年在丹江口地区发现的新石器时代-东周时期人类遗骸及相关研究</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=ZHOU Mi&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 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href="/patent-detail/06120100880727.html">一种针对DNA含量极低的古代人类遗骸性别鉴定方法</a> <b>[P]</b> . <span> 中国专利： CN110055337A </span> <span> . 2019-07-26</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120103662835.html">应用全基因组捕获转座子间区段序列对受微生物污染的人类DNA样本进行基因组序列分析</a> <b>[P]</b> . <span> 中国专利： CN110914454A </span> <span> . 2020-03-24</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130409469106.html">rna targeting dna; DNA polynucleotide; recombinant expression vector; genetically modified host cell in vitro; variant site-directed modification polypeptide; chimeric site-directed modification polypeptide; rna polynucleotide; genetically modified cell; transgenic non-human organism whose genome comprises a transgene; composition; site specific modification method of a target DNA; site specific transcriptional modulation method within a target DNA; site-specific modification method in target DNA; method of promoting site-specific cleavage and modification of a target DNA in a cell; method of producing a genetically modified cell in a subject; method of modifying target DNA in a genetically modified cell; kit; target dna target kit; method of selectively modulating transcription of a target DNA into a host cell; isolated nucleic acid; genetically modified host cell; and nucleic acid library</a> <b>[P]</b> . <span> 外国专利：  BR112014029441A2 </span> <span> . 2017-06-27</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：针对dna的rna; DNA多核苷酸;重组表达载体体外转基因宿主细胞;变体定点修饰多肽;嵌合定点修饰多肽; rna多核苷酸;转基因细胞基因组包含转基因的转基因非人类生物;组成;靶DNA的位点特异性修饰方法;靶DNA内的位点特异性转录调节方法;靶DNA的位点特异性修饰方法;促进细胞中靶DNA的位点特异性切割和修饰的方法;在受试者中产生基因修饰的细胞的方法;在转基因细胞中修饰靶DNA的方法;套件目标dna目标试剂盒;选择性调节靶DNA转录到宿主细胞中的方法;分离的核酸转基因宿主细胞;和核酸文库 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130408532282.html">Determination of the content of the GC-rich genome sequence (GC-DNA) in the circulating extracellular DNA of peripheral blood plasma as a way to determine the level of cell death in chronic diseases, physiological conditions (pregnancy) and the chronic effects of adverse environmental factors on the human body</a> <b>[P]</b> . <span> 外国专利：  RU2015117686A </span> <span> . 2016-12-10</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：确定外周血浆循环细胞外DNA中富含GC的基因组序列（GC-DNA）的含量，以确定慢性疾病，生理状况（怀孕）和不良反应的慢性影响中细胞死亡的水平人体环境因素 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130440943934.html">PERFUME COMPOSITION FOR HAIR DECOLORING AGENT OF ONE AGENT TYPE, HAIR DECOLORING AGENT OF ONE AGENT TYPE CONTAINING THE PERFUME COMPOSITION, AND METHOD FOR DECOLORING HAIR BY USING THE HAIR DECOLORING AGENT</a> <b>[P]</b> . <span> 外国专利：  JP2005075821A </span> <span> . 2005-03-24</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：一剂类型的头发脱色剂的香水组合物，一种包含香水组合物的一种剂型的头发脱色剂以及使用该头发脱色剂的头发脱色方法 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="ywcd('0704022536141','4',7,2,1,'',this,24)" class="delivery" prompt="010401" title="通过人工服务将文献原文发送至邮箱" >获取原文</div> <div class="journalsub-pop-up" style="display: none"> <div class="journal-sub"> <h2>期刊订阅</h2> <img 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