Prognostic Value of the Expression of DNA Repair–Related Biomarkers Mediated by Alcohol in Gastric Cancer Patients

摘要

Alcohol consumption likely induces gastric carcinogenesis through deregulation of RNA polymerase (Pol) III genes and oxidative damage. Transcription factor IIB-related factor 1 (BRF1) overexpression alleviates RNA Pol III transcription inhibition through breast cancer susceptibility gene 1 (BRCA1). Myeloperoxidase (MPO) involvement in cancer is induced by alcohol-mediated oxidative damage. BRCA1/2 and MPO play key roles in DNA repair. BRCA1 and BRCA2 exert different roles in homologous recombination repair. By using human gastric cancer (GC) biopsies, we investigated the prognostic value of these proteins upon alcohol induction. In total, high expression of BRF1 ( P ?=?0.010) and positive cell infiltration of MPO ( P ?=?0.004) in tumor tissues as well as positive expression of BRCA1 ( P ? P ?=?0.021), BRCA2 ( P ? P ?=?0.039) were independent prognostic factors for disease-free survival. BRCA1 ( P ?=?0.005) and BRCA2 ( P ? P ?