Major health impact of accelerated aging in young HIV-infected individuals on antiretroviral therapy

Rajasuriar Reena; Chong Meng L.; Bashah Nor S. Ahmad; Aziz Siti A. Abdul; Mcstea Megan; Lee Erica C. Y.; Wong Pui L.; Azwa Iskandar; Omar Sharifah F. Syed; Lai Pauline S. M.; Ponampalavanar Sasheela; Crowe Suzanne M.; Lewin Sharon R.; Kamaruzzaman Shahrul B.; Kamarulzaman Adeeba

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Major health impact of accelerated aging in young HIV-infected individuals on antiretroviral therapy

机译：加速老龄化在抗逆转录病毒治疗中幼苗感染个体的主要健康影响

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Background: Aging among HIV-infected individuals on antiretroviral therapy (ART) is a significant clinical challenge; however, studies assessing multidimensional aspects of aging are lacking. We characterized 10 geriatric conditions encompassing multiple functional domains, its health impact and associated risk factors in HIV-infected and age-matched uninfected controls.

机译：背景：抗逆转录病毒治疗（ART）的艾滋病毒感染的个体中的老化是一个重要的临床挑战; 然而，缺乏评估衰老多维方面的研究。我们在艾滋病毒感染和年龄匹配的未感染控制中表征了10个包含多种功能域的老茧病症，其健康影响和相关的危险因素。

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来源
《AIDS》 |2017年第10期|共11页
作者
Rajasuriar Reena; Chong Meng L.; Bashah Nor S. Ahmad; Aziz Siti A. Abdul; Mcstea Megan; Lee Erica C. Y.; Wong Pui L.; Azwa Iskandar; Omar Sharifah F. Syed; Lai Pauline S. M.; Ponampalavanar Sasheela; Crowe Suzanne M.; Lewin Sharon R.; Kamaruzzaman Shahrul B.; Kamarulzaman Adeeba;
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作者单位

Univ Malaya Fac Med Ctr Excellence Res AIDS Kuala Lumpur 50603 Malaysia;

Univ Malaya Fac Med Ctr Excellence Res AIDS Kuala Lumpur 50603 Malaysia;

Univ Malaya Fac Med Ctr Excellence Res AIDS Kuala Lumpur 50603 Malaysia;

Univ Malaya Fac Med Ctr Excellence Res AIDS Kuala Lumpur 50603 Malaysia;

Univ Malaya Fac Med Ctr Excellence Res AIDS Kuala Lumpur 50603 Malaysia;

Univ Malaya Fac Med Ctr Excellence Res AIDS Kuala Lumpur 50603 Malaysia;

Univ Malaya Fac Med Ctr Excellence Res AIDS Kuala Lumpur 50603 Malaysia;

Univ Malaya Fac Med Ctr Excellence Res AIDS Kuala Lumpur 50603 Malaysia;

Univ Malaya Fac Med Ctr Excellence Res AIDS Kuala Lumpur 50603 Malaysia;

Univ Malaya Dept Primary Care Med Kuala Lumpur Malaysia;

Univ Malaya Fac Med Ctr Excellence Res AIDS Kuala Lumpur 50603 Malaysia;

Monash Univ Dept Infect Dis Melbourne Vic Australia;

Univ Melbourne Peter Doherty Inst Infect &

Immun Melbourne Vic Australia;

Univ Malaya Dept Med Fac Med Geriatr Unit Kuala Lumpur Malaysia;

Univ Malaya Fac Med Ctr Excellence Res AIDS Kuala Lumpur 50603 Malaysia;

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原文格式 PDF
正文语种 eng
中图分类传染病;
关键词
aging; geriatric conditions; health outcomes; mortality risk scores; polypathology; quality of life;

机译：老化;老年人;健康结果;死亡风险分数;polypoishology;生活质量;

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专利

1. Major health impact of accelerated aging in young HIV-infected individuals on antiretroviral therapy [J] . Rajasuriar Reena, Chong Meng L., Bashah Nor S. Ahmad, AIDS . 2017,第10期

机译：加速老龄化在抗逆转录病毒治疗中幼苗感染个体的主要健康影响
2. Baseline Immune Phenotypes and CD4+ T Lymphocyte Responses to Antiretroviral Therapy in Younger versus Older HIV-infected Individuals [J] . Risa M. Hoffman, Beth D. Jamieson, Ronald J. Bosch, Journal of Clinical Immunology . 2011,第5期

机译：艾滋病毒感染者的基线免疫表型和CD4 + T淋巴细胞对抗逆转录病毒疗法的反应
3. Impact of Genetic and Nongenetic Factors on Body Mass Index and Waist-Hip Ratio Change in HIV-Infected Individuals Initiating Antiretroviral Therapy [J] . Catalina Barceló, Monia Guidi, Christian W Thorball, Open Forum Infectious Diseases . 2020,第1期

机译：遗传和环境因素对艾滋病毒感染众年人体重指数和腰臀比发生抗逆转录病毒治疗的影响
4. Effect of highly active antiretroviral therapy (HAART) on lipid abnormalities in HIV-infected patients [C] . Estari Mamidala 2011 international conference on medical information and bioengineering. . 2011

机译：高效抗逆转录病毒疗法（HAART）对HIV感染患者血脂异常的影响
5. Trends in cancer and development of AIDS in HIV-infected individuals before and after implementation of highly active antiretroviral therapy. [D] . Martin, Rose Marie. 2010

机译：在实施高效抗逆转录病毒治疗前后，艾滋病毒感染者的癌症和艾滋病发展趋势。
6. ATM Deficiency Accelerates DNA Damage Telomere Erosion and Premature T Cell Aging in HIV-Infected Individuals on Antiretroviral Therapy [O] . Juan Zhao, Lam Ngoc Thao Nguyen, Lam Nhat Nguyen, 2019

机译：ATM缺乏加速DNA损伤端粒损伤抗逆转录病毒治疗中的艾滋病毒感染个体造成的侵蚀和早产T细胞老化
7. ATM Deficiency Accelerates DNA Damage, Telomere Erosion, and Premature T Cell Aging in HIV-Infected Individuals on Antiretroviral Therapy [O] . Juan Zhao, Lam Ngoc Thao Nguyen, Lam Nhat Nguyen, 2019

机译：ATM缺乏加速DNA损伤，端粒损伤，抗逆转录病毒治疗中的艾滋病毒感染个体造成的侵蚀和早产T细胞老化

Major health impact of accelerated aging in young HIV-infected individuals on antiretroviral therapy

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