CYP2B6 genotype-directed dosing is required for optimal efavirenz exposure in children 3-36 months with HIV infection

Moore Carolyn Bolton; Capparelli Edmund V.; Samson Pearl; Bwakura-Dangarembizi Mutsa; Jean-Philippe Patrick; Worrell Carol; Heckman Barbara; Purdue Lynette; Spector Stephen A.; Benns Alex; Borkowsky William; Loftis Amy; Hawkins Elizabeth; Wallis Carole; Chadwick Ellen G.

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CYP2B6 genotype-directed dosing is required for optimal efavirenz exposure in children 3-36 months with HIV infection

机译：CYP2B6基因型定向剂量是在3-36个月儿童艾滋病毒感染3-36个月内的最佳eFaviraenz暴露所必需的

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Objectives: To determine safety-specific, efficacy-specific and genotypic-specific dose requirements of efavirenz (EFV) in children aged 3 to less than 36 months with HIV infection.

机译：目的：以艾滋病毒感染确定3至36个月的儿童的efavirenz（EFV）的安全特异性，疗效特异性和基因型特异性剂量要求。

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来源
《AIDS》 |2017年第8期|共8页
作者
Moore Carolyn Bolton; Capparelli Edmund V.; Samson Pearl; Bwakura-Dangarembizi Mutsa; Jean-Philippe Patrick; Worrell Carol; Heckman Barbara; Purdue Lynette; Spector Stephen A.; Benns Alex; Borkowsky William; Loftis Amy; Hawkins Elizabeth; Wallis Carole; Chadwick Ellen G.;
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作者单位

Ctr Infect Dis Res Zambia POB 34681 Lusaka 10101 Zambia;

Univ Calif San Diego La Jolla CA 92093 USA;

Harvard TH Chan Sch Publ Hlth Boston MA USA;

Univ Zimbabwe Harare Zimbabwe;

NIAID 9000 Rockville Pike Bethesda MD 20892 USA;

Eunice Kennedy Shriver Natl Inst Child Hlth &

Hum NIH Bethesda MD USA;

Frontier Sci &

Technol Res Fdn Inc Amherst NY USA;

NIAID 9000 Rockville Pike Bethesda MD 20892 USA;

Univ Calif San Diego La Jolla CA 92093 USA;

Frontier Sci &

Technol Res Fdn Inc Amherst NY USA;

NYU Sch Med New York NY USA;

Univ North Carolina Chapel Hill UNC Global Hlth &

Infect Dis Chapel Hill NC USA;

Social &

Sci Syst Inc Silver Spring MD USA;

BARC SA &

Lancet Labs Johannesburg South Africa;

Northwestern Univ Feinberg Sch Med Chicago IL 60611 USA;

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原文格式 PDF
正文语种 eng
中图分类传染病;
关键词
children; CYP2B6 G516T genotype; efavirenz; HIV; pharmacokinetics; treatment;

机译：儿童;CYP2B6 G516T基因型;efaviraz;艾滋病毒;药代动力学;治疗;

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专利

1. CYP2B6 genotype-directed dosing is required for optimal efavirenz exposure in children 3-36 months with HIV infection [J] . Moore Carolyn Bolton, Capparelli Edmund V., Samson Pearl, AIDS . 2017,第8期

机译：CYP2B6基因型定向剂量是在3-36个月儿童艾滋病毒感染3-36个月内的最佳eFaviraenz暴露所必需的
2. Tribal ethnicity and CYP2B6 genetics in Ugandan and Zimbabwean populations in the UK: implications for efavirenz dosing in HIV infection. [J] . Jamshidi Y, Moreton M, McKeown DA, The Journal of Antimicrobial Chemotherapy . 2010,第12期

机译：英国乌干达和津巴布韦人群的部落种族和CYP2B6遗传学：依非韦伦剂量在HIV感染中的影响。
3. Mid-dosing interval efavirenz plasma concentrations in HIV-1-infected children in Rwanda: Treatment efficacy, tolerability, adherence, and the influence of CYP2B6 polymorphisms [J] . MutwaP.R., FillekesQ., MalgazM., JAIDS: Journal of acquired immune deficiency syndromes . 2012,第4期

机译：卢旺达HIV-1感染儿童的中剂量间隔依法韦仑血浆浓度：治疗效果，耐受性，依从性和CYP2B6多态性的影响
4. An Application of Gradual Reduction of Drug Dose to HIV Infection Model in Consideration of Drug Resistance and Drug Dose [C] . H. Chang, Nam H. Jo, H. Shim SICE-ICASE International Joint Conference . 2006

机译：逐步减少药物剂量对耐药剂药物剂量对HIV感染模型的应用
5. HIV Infection and its association with Caries and the Salivary Microbiota in Nigerian Children aged 6 to 72 months. [D] . Coker, Modupe O. 2015

机译：6到72个月大的尼日利亚儿童中的HIV感染及其与龋齿和唾液微生物群的关系。
6. CYP2B6 Genotype-directed dosing is required for optimal efavirenz exposure in children 3 to 36 months with HIV infection [O] . Carolyn Bolton MOORE, Edmund V. CAPPARELLI, Pearl SAMSON, -1

机译：对于感染HIV的3到36个月的儿童最佳的依非韦伦暴露量需要以CYP2B6基因型为导向的剂量
7. Revised Surveillance Case Definitions for HIV Infection Among Adults, Adolescents, and Children Aged 18 Months and HIV Infections and AIDS Among Children Aged 18 Months to 13 Years - United States, 2008. Morbidity and Mortality Weekly Report, Vol. 57, No [R] . 2008

机译：修订了18个月内成人，青少年和18个月的儿童艾滋病毒感染监测病例定义和18个月至13岁儿童的艾滋病毒感染和艾滋病 - 美国，2008年。发病率和死亡率每周报告，第一卷。 57，没有

CYP2B6 genotype-directed dosing is required for optimal efavirenz exposure in children 3-36 months with HIV infection

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