Plasma soluble CD163 is associated with postmortem brain pathology in human immunodeficiency virus infection

Bryant Alex K.; Moore David J.; Burdo Tricia H.; Lakritz Jessica R.; Gouaux Ben; Soontornniyomkij Virawudh; Achim Cristian L.; Masliah Eliezer; Grant Igor; Levine Andrew J.; Ellis Ronald J.

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Plasma soluble CD163 is associated with postmortem brain pathology in human immunodeficiency virus infection

机译：血浆可溶性CD163与人类免疫缺陷病毒感染中的后期脑病理有关

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Objective: Higher plasma soluble cluster of differentiation (CD) 163 (sCD163), shed by monocytes and macrophages, correlates with neurocognitive impairment in HIV infection. We hypothesized that higher antemortem plasma or cerebrospinal fluid (CSF) sCD163 would be associated with greater postmortem neurodegeneration and/or microgliosis.

机译：目的：较高的血浆可溶性分化（CD）163（SCD163），由单核细胞和巨噬细胞脱落，与艾滋病毒感染中的神经认知障碍相关。我们假设较高的抗eVortem血浆或脑脊液（CSF）SCD163将与更高的后期神经变性和/或微细胞源相关。

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《AIDS》 |2017年第7期|共7页
作者
Bryant Alex K.; Moore David J.; Burdo Tricia H.; Lakritz Jessica R.; Gouaux Ben; Soontornniyomkij Virawudh; Achim Cristian L.; Masliah Eliezer; Grant Igor; Levine Andrew J.; Ellis Ronald J.;
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作者单位

Univ Calif San Diego HIV Neurobehav Res Program La Jolla CA 92093 USA;

Univ Calif San Diego HIV Neurobehav Res Program La Jolla CA 92093 USA;

Temple Univ Lewis Katz Sch Med Dept Neurosci Philadelphia PA 19122 USA;

Boston Coll Dept Biol Chestnut Hill MA 02167 USA;

Univ Calif San Diego HIV Neurobehav Res Program La Jolla CA 92093 USA;

Univ Calif San Diego HIV Neurobehav Res Program La Jolla CA 92093 USA;

Univ Calif San Diego HIV Neurobehav Res Program La Jolla CA 92093 USA;

Univ Calif San Diego HIV Neurobehav Res Program La Jolla CA 92093 USA;

Univ Calif San Diego HIV Neurobehav Res Program La Jolla CA 92093 USA;

Univ Calif Los Angeles Dept Neurol Los Angeles CA 90024 USA;

Univ Calif San Diego HIV Neurobehav Res Program La Jolla CA 92093 USA;

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原文格式 PDF
正文语种 eng
中图分类传染病;
关键词
AIDS; antiretroviral therapy; brain; HIV; mild cognitive impairment; neurodegenerative disorders;

机译：艾滋病;抗逆转录病毒治疗;脑;艾滋病毒;轻度认知障碍;神经变性障碍;

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专利

1. Plasma soluble CD163 is associated with postmortem brain pathology in human immunodeficiency virus infection [J] . Bryant Alex K., Moore David J., Burdo Tricia H., AIDS . 2017,第7期

机译：血浆可溶性CD163与人类免疫缺陷病毒感染中的后期脑病理有关
2. Macrophage Activation Marker Soluble CD163 Is a Dynamic Marker of Liver Fibrogenesis in Human Immunodeficiency Virus/Hepatitis C Virus Coinfection [J] . Lidofsky Anna, Holmes Jacinta A., Feeney Eoin R., The Journal of Infectious Diseases . 2018,第9期

机译：巨噬细胞活化标志物可溶性CD163是人免疫缺陷病毒/丙型肝炎病毒繁殖中肝纤维发生的动态标志物
3. Soluble CD163 Is Associated With Noninvasive Measures of Liver Fibrosis in Hepatitis C Virus- and Hepatitis C Virus/Human Immunodeficiency Virus-Infected Women [J] . Kuniholm Mark H., Hanna David B., Landay Alan L., Hepatology: Official Journal of the American Association for the Study of Liver Diseases . 2015,第2期

机译：可溶性CD163与丙型肝炎病毒和丙型肝炎病毒/人类免疫缺陷病毒感染妇女的肝纤维化的非侵入性措施相关
4. Disruption of brain network organization in patients with human immunodeficiency virus (HIV) infection [C] . Silvia Minosse, Eliseo Picchi, Francesca Di Giuliano, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2020

机译：人类免疫缺陷病毒（HIV）感染患者脑网络组织的破坏
5. The Effects of Human Immunodeficiency Virus (HIV) Infection on Host DNA Methylation and Plasma Microbiome. [D] . Li, Sai Kam. 2011

机译：人类免疫缺陷病毒（HIV）感染对宿主DNA甲基化和血浆微生物组的影响。
6. Plasma soluble CD163 is associated with postmortem brain pathology in human immunodeficiency virus infection [O] . Alex K. BRYANT, David J. MOORE, Tricia H. BURDO, -1

机译：血浆可溶性CD163与人类免疫缺陷病毒感染的死后脑部病理学相关
7. Plasma soluble CD163 is associated with postmortem brain pathology in human immunodeficiency virus infection [O] . Alex K. Bryant, David J. Moore, Tricia H. Burdo, 2017

机译：血浆可溶性CD163与人类免疫缺陷病毒感染中的后脑病病理相关
8. Association of Mycoplasma and Human Immunodeficiency Virus Infection: Detectionof Amplified Mycoplasma Fermentans DNA in Blood [R] . Hawkins, R. E., Rickman, L. S., Vermund, S. H., 1992

机译：支原体与人类免疫缺陷病毒感染的关联：血液中放大的支原体发酵DNa的检测

Plasma soluble CD163 is associated with postmortem brain pathology in human immunodeficiency virus infection

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