gamma delta T-cell subsets in HIV controllers: potential role of T gamma delta 17 cells in the regulation of chronic immune activation

摘要

Objectives: HIV controllers (HICs) are rare HIV-infected individuals able to maintain undetectable viremia in the absence of antiretroviral treatment. Although HIV-specific cytotoxic T cells have been well deciphered in HIC, gamma delta T lymphocytes remain largely uncharacterized. The aim of this study was to analyse phenotypic and functional characteristics of gamma delta T cells and their relationship with immune activation, which remains abnormally elevated and associated with comorbidities in HICs.