ANTI-PROLIFERATIVE EFFECTS OF INOSITOL HEXAPHOSPHATE AND VERAPAMIL ON HUMAN COLON CANCER CACO-2 AND HT-29 CELLS

摘要

Inositol hexaphosphate (IP6, phytic acid), a natural dietary ingredient, is also found in mammalian cells at concentrations as high as 1 mM (1). It has shown a significant anti-cancer effects in various in vivo and in vitro models, including breast, prostate, liver and colon carcinomas (2-7). Concomitant to inhibition of cancer cell growth, cellular differentiation has also been reported in divergent cancer cell lines (8).