Genome-wide association study of Alzheimer's disease endophenotypes at prediagnosis stages

Chung Jaeyoon; Wang Xulong; Maruyama Toru; Ma Yiyi; Zhang Xiaoling; Mez Jesse; Sherva Richard; Takeyama Haruko; Lunetta Kathryn L.; Farrer Lindsay A.; Jun Gyungah R.

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Genome-wide association study of Alzheimer's disease endophenotypes at prediagnosis stages

机译：术治疗Alzheimer疾病的基因组关联研究

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Introduction: Genetic associations for endophenotypes of Alzheimer's disease (AD) in cognitive stages preceding AD have not been thoroughly evaluated.

机译：介绍：在广告中的认知阶段中阿尔茨海默病（AD）的内胚口遗传关联尚未彻底评估。

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《Alzheimer’s & dementia: the journal of the Alzheimer’s Association》 |2018年第5期|共11页
作者
Chung Jaeyoon; Wang Xulong; Maruyama Toru; Ma Yiyi; Zhang Xiaoling; Mez Jesse; Sherva Richard; Takeyama Haruko; Lunetta Kathryn L.; Farrer Lindsay A.; Jun Gyungah R.;
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作者单位

Boston Univ Bioinformat Grad Program Boston MA 02215 USA;

Eisai Inc Andover Innovat Med AiM Inst Neurogenet &

Integrated Genom Andover MA 01845 USA;

Waseda Univ Dept Life Sci &

Med Biosci Tokyo Japan;

Boston Univ Dept Med Biomed Genet Boston MA 02215 USA;

Boston Univ Dept Med Biomed Genet Boston MA 02215 USA;

Boston Univ Dept Neurol Boston MA 02215 USA;

Boston Univ Dept Med Biomed Genet Boston MA 02215 USA;

Waseda Univ Dept Life Sci &

Med Biosci Tokyo Japan;

Boston Univ Dept Biostat Boston MA 02215 USA;

Boston Univ Bioinformat Grad Program Boston MA 02215 USA;

Boston Univ Dept Med Biomed Genet Boston MA 02215 USA;

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原文格式 PDF
正文语种 eng
中图分类神经病学与精神病学;
关键词
Alzheimer's disease; Genome-wide association; Endophenotypes; Cerebrospinal fluid; MRI; Logical memory; Biomarker; ADNI; Tau; Coexpression network;

机译：阿尔茨海默病;基因组 - 宽协会;内心型;脑脊液;MRI;逻辑记忆;生物标志物;ADNI;TAU;CO表达网络;

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专利

1. Genome-wide association study of Alzheimer's disease endophenotypes at prediagnosis stages [J] . Chung Jaeyoon, Wang Xulong, Maruyama Toru, Alzheimer’s & dementia: the journal of the Alzheimer’s Association . 2018,第5期

机译：术治疗Alzheimer疾病的基因组关联研究
2. Endophenotypes as Disease Modifiers: Decoding the Biology of Alzheimer's by Genome-wide Association Studies [J] . Neelakandan A. R., Rajanikant G. K. CNS & neurological disorders drug targets . 2018,第1期

机译：Endopheopootypes作为疾病修饰剂：通过基因组协会研究解码阿尔茨海默氏症的生物学
3. Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers [J] . Deming Yuetiva, Li Zeran, Kapoor Manav, Acta Neuropathologica . 2017,第5期

机译：基因组关联研究鉴定了与阿尔茨海默氏症的内心型和疾病改性剂相关的四种新锁骨菌
4. VariFunNet, an integrated multiscale modeling framework to study the effects of rare non-coding variants in genome-wide association studies: Applied to Alzheimer's disease [C] . Qiao Liu, Chen Chen, Annie Gao, IEEE International Conference on Bioinformatics and Biomedicine . 2017

机译：VariFunNet，一个集成的多尺度建模框架，用于研究全基因组关联研究中罕见的非编码变体的影响：应用于阿尔茨海默氏病
5. The Association of Cognitive Endophenotypes and Risky Single Nucleotide Polymorphisms of Alzheimer's Disease within the Alzheimer's Disease Neuroimaging Initiative (ADNI) Database. [D] . Jennette, Kyle J. 2015

机译：在阿尔茨海默氏病神经影像学倡议（ADNI）数据库中，阿尔茨海默氏病的认知内在表型与危险的单核苷酸多态性的关联。
6. Genome-Wide Association Study of Alzheimer Disease Endophenotypes at Prediagnosis Stages [O] . Jaeyoon Chung, Xulong Wang, Toru Maruyama, -1

机译：全基因组关联研究在阿尔茨海默氏病预诊断阶段的表型
7. Genome-wide association study of Alzheimer's disease endophenotypes at prediagnosis stages [O] . Jaeyoon Chung, Xulong Wang, Toru Maruyama, 2017

机译：基因组 - Alzheimer疾病内蛋白在倾斜阶段的疾病学会

Genome-wide association study of Alzheimer's disease endophenotypes at prediagnosis stages

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