Lubricant Provides Poor Rectal Mucosal HIV Coverage

摘要

99m Tc-DTPA-radiolabeled hydroxyethyl cellulose universal placebo gel intrarectally. After washout, participants received 10?ml of radiolabeled Wet ? Original ? lubricant to apply to the anus with fingers and/or a phallus in a manner typical of sexual lubricant use with a partner, followed by simulated receptive anal intercourse. Single-photon emission computed tomography with transmission computed tomography was performed 4?h after each gel administration. Manual dosing was associated with more variable rectosigmoid distribution, 4.4–15.3?cm from the anorectal junction, compared with more uniform distribution, 5.9–7.4 and 5.3–7.6?cm after 10 and 3.5?ml applicator dosing, respectively. A significantly smaller fraction of the initial 10?ml dose was retained within the colon after manual dosing, 3.4%, compared with 94.9% and 88.4% after 10 and 3.5?ml applicator dosing, respectively (both p ?