Short Communication: The Clinical Value of Cystatin C as a Marker of Renal Function in HIV Patients Receiving Dolutegravir

摘要

t -test to assess the changes in estimated glomerular filtration rate (eGFR) calculated by serum creatinine or cystatin C level, after the start of cART. In all 18 patients, only 2 cases were naive, whereas 16 cases switched treatment. Based on serum creatinine level, eGFR significantly changed from 67.9 (61.2–95.7) ml/min per 1.73?m 2 [medians and interquartile ranges ] to 63.6 (55.5–83.7) ml/min per 1.73?m 2 ( p ?=?.0004). Conversely, eGFR was almost unchanged [79.8 (77.7–82.5) to 80.0 (77.1–82.5) ml/min per 1.73?m 2 ; p ?=?.132] when serum cystatin C level was used for estimation. In HIV patients receiving DTG, measurement of serum cystatin C as an alternative renal function test might be clinically valuable because it is not affected by DTG administration.]]>