Preparation and characterization of poly(acrylic acid-co-methyl methacrylate) microparticles as sustained drug delivery system of antihypertensive drugs

摘要

The objective of the present study was to develop a sustained drug delivery system for highly water-soluble (diltiazem hydrochloride and metoprolol tartrate) drugs using pH sensitive monomers (acrylic acid and methyl methacrylate). The monomers were polymerized using ammonium persulphate as initiator. The polymers were then cross-linked with ethyleneglycol dimethacrylate as crosslinking agent. The prepared microparticles were characterized by FT-IR and DSC for drug and polymer compatibility and surface morphology of the particles was studied by SEM. FT-IR and DSC studies showed no chemical interaction between the drug and polymers. The release of drug followed Non Fickian diffusion type.